Dr. Randy Cron speaks about the identification of perforin as the first

gene determined to be defective in patients with familial hemophagocytic

lymphohistiocytosis.

Dr. Janis Burkhardt discusses two articles that advanced the

understanding of the immunological synapse.

Dr. Steven Reiner talks about the publication that identified the transcription factor T-bet, a key factor in Type-I immunity.

Dr. Klaus Rajewsky discusses the publication in 2002 of a DNA deamination model of somatic antibody diversification.

Dr. Graham Anderson talks about the identification in 1994 of the gene

responsible for defective thymus development in nude mice.

Dr. Pamela Bjorkman speaks about how the 1993 publication of the first

crystal structure of a class II MHC protein impacted the field.

Dr. Bill Nauseef discusses a 1973 article that looked at the role of superoxide anion as the product of phagocyte oxidase.

Dr. Larry Kane discusses a 1994 article that established that T cell receptor signal transduction is initiated by the sequential interaction of two tyrosine kinases with the TCR.”

Dr. Alan Aderem discusses two articles by George Mackaness who demonstrated that macrophages can serve as effector cells for acquired cell-mediated immunity.

Dr. Lewis Lanier discusses the work of the late Leonard Herzenberg and the early days of FACS.