Dr. Jeffrey Bluestone discusses three articles published in 2003 that describe the discovery of

FOXP3 as the determinant of Treg cell fate and function.

Dr. Finkelman discusses two 1966 articles from The Journal of Immunology on the identification of IgE as the allergy-associated immunoglobulin isotype.

Dr. Michael Cancro speaks about a 1992 article describing the molecule (now termed CD154) that transduces the signal for Th-dependent B

cell activation.

Dr. Kristen Hogquist discusses two of the most highly cited papers in the 100-year history of The Journal of Immunology, papers which describe the function or characterization of monoclonal antibodies to the human and mouse T cell receptors.

Dr. Gabriel Núñez speaks about a 1999 article by Shizuo Akira’s group which showed by both functional and genetic studies that TLR4 is the receptor for LPS.

Dr. Jay Kolls discusses three foundational articles published in The Journal of Immunology about the function of IL-10, two by Fiorentino and colleagues in 1991 and one by Steinbrink et al. in 1997.

Dr. Robert Fairchild discusses a 1983 article by Bass and coworkers on the use of flow cytometry in the intracellular analysis of NADPH

oxidase function in human neutrophils.

Dr. Frank Fitch discusses a 1978 article describing an assay for T cell growth factor (later renamed IL-2) and its application in the study of lymphocytes.

Dr. Anne O'Garra talks about the 1997 work of Zheng and Flavell on the role of GATA-3 in Th2

cytokine gene expression in CD4 T cells.

Dr. Willi Born discusses two 1986 articles by Brenner and Bank and their colleagues, on the

discovery of the gamma-delta T-cell receptor.