Dr. James Hagman discusses a 1997 paper from the laboratory of Tak Mak,

which first described the phenotype of T and B cells in mice lacking IRF4.

Dr. Jane Buckner discusses 1974 papers from Bottazzo and MacCuish that were instrumental in determining that autoantibodies are directed at pancreatic islet cells in type I diabetes.

Dr. Klaus Ley discusses Charles Mills’ 2000 article, published in The JI, describing the M1/M2 polarization axis of macrophages.

Dr. Pamela Schwartzberg discusses Cox Terhorst’s 1998 paper published in Nature that identified the gene encoding the SLAM protein SAP, which was later found to be mutated in X-linked proliferative syndrome.

Dr. Andrea Cooper discusses Ian Orme’s seminal work, published in 1987 in The JI, describing the kinetics, phenotype, and function of T cells responding to Mycobacterium tuberculosis.

Dr. Ranjan Sen discusses a 2000 article from the Krangel group that identified a chromatin-based mechanism for the regulation of V(D)J recombination.

Dr. Gabrielle Belz discusses a 1998 article from the Steinman group that revealed that monocytes could respond to a variety of cues, including non-cytokine cues, to differentiate into dendritic cells.

Dr. Reinhard Hohlfeld discusses a 1981 article describing the isolation and transfer of antigen-specific T lymphocytes capable of mediating autoimmune encephalomyelitis.

Dr. Glenn Dranoff talks about a 1984 article on the cloning of Granulocyte-Macrophage Colony Stimulating Factor.

Dr. Jiri Mestecky discusses a 1974 article in The JI on Per Brandtzaeg’s model for transport of

secretory IgA.