The Journal of Immunology ImmunoCasts

Dr. Katherine Fitzgerald discusses a 2002 paper by Jürg Tschopp and colleagues that first defined the formation of the inflammasome complex.

Dr. Katherine Fitzgerald discusses a 2002 paper by Jürg Tschopp and colleagues that first defined the formation of the inflammasome complex.

Dr. Claudia Kemper discusses a 1985 PNAS paper that first identified CD46, a key regulatory molecule in the complement system.

Dr. Todd Fehniger discusses two seminal papers that demonstrated a role for IL-15 in the development and survival of natural killer cells.

Dr. Alberto Martin discusses A 1985 paper demonstrating that cancer could be caused by a non-mutated version of Myc

Dr. Craig Bassing discusses a 1993 Science paper by Frederick Alt that demonstrating a role for RAG2 in T cell development.

Dr. Shabaana Khader discusses a 2003 Nature paper by Daniel

Cua that defined a specific role for IL-23 in autoimmune inflammation.

Drs. Bethany Moore and Steven Kunkel discuss a 1987 PNAS paper that first identified a chemotactic cytokine that would eventually be known as IL-8.

Dr. Dr. Mark Kaplan discusses a 1989 Science paper by Gerald Crabtree that demonstrated the mechanism by which cyclosporin A inhibited T cell activation.

Dr. Uttiya Basu discusses a 1999 paper by the group of Tasuku Honjo that demonstrates a critical role for activation-induced cytidine deaminase in class switch recombination and somatic hypermutation of B cells.