Dr. Diane Mathis speaks about work from Bruno Kyewski’s group on the role of thymic expression of

peripheral tissue antigens in the induction of central tolerance.

Dr. Littman discusses work by Al Singer’s group on the “kinetic signaling” model of T cell lineage choice.

Dr. Unanue talks about about the work of Rudensky and colleagues on the

sequence analysis of peptides bound to MHC class II molecules.

Dr. Gwen Randolph speaks about the seminal work of Reinhold Förster

and colleagues on the role of CCR7 in the primary immune response.

Dr. Michael Krangel discusses an article from Mark Schlissel and

colleagues that showed for the first time that chromatin structure determines the targeting

of V(D)J recombinase activity.

Dr. Chandra Mohan discusses the 1994 article by Ward Wakeland and

colleagues that described the chromosomal locations of genetic loci linked to murine

lupus.

Dr. David Raulet talks about two 1971 articles by Cudkowicz and Bennett

which examined rejection of allogeneic cells and the phenomenon of hybrid resistance.

Dr. Michael Gale speaks about the discovery in 1957 of type I interferon

by Alick Isaacs and Jean Lindenmann.

Dr. Suzanne Cory discusses the 1999 publication that described how

commitment to the B-lymphoid lineage depends on the transcription factor Pax5.

Dr. David Fox discusses a 1998 article by Schellekens et al. which showed that the amino acid citrulline was an essential component of the determinant recognized by anti-fillagrin autoantibodies in rheumatoid arthritis.