In Part 2 of our focus this month on ‘Understanding Pain in 2026’, we take a look at Predictive Processing (the brain guessing what is happening and outputting pain when it predicts danger) and Active Inference (the brain acting to confirm or update these guesses, shaping how you move, feel, and interpret sensations).
Joining host Matt Phillips of Runchatlive.com are special guests Professor Dave Newell, Head of The Centre for Pain & Active Inference Research at Health Sciences University, and Anna Maria Mazzieri, a PhD student at Health Sciences University, and Director of The ST School.
The episode discusses how the brain builds models, predicts sensory input, and acts to minimize prediction error - shaping movement, sensation and chronic pain. The conversation covers embodiment, precision, therapeutic alliance, and practical implications for clinicians, including sense-making, creating safe liminal spaces, graded exposure and using touch as a communication tool.
Listeners are invited & encouraged to re-listen for deeper understanding and to use the episode’s insights to rethink clinical reasoning and patient-centred approaches to pain management.
00:00:00 - Welcome to the STA Clinician Podcast00:01:38 - Meet Professor Dave Newell and Anna Maria Mazzieri00:03:25 - Anna-Maria’s PhD Journey00:05:22 - The Centre for Pain & Active Inference Research00:06:58 - Understanding Active Inference00:15:46 - The Role of Active Inference00:21:35 - Clinical Applications of Active Inference00:23:17 - Contextual Factors in Pain00:29:46 - The Concept of Self-Evidencing00:37:38 - Chronic Pain and Active Inference00:38:35 - Listener Questions00:42:15 - Therapeutic Alliance in Pain Management00:45:50 - Co-Creation in Therapy00:48:30 - The Complexity of Pain00:53:42 - Conclusion and Next StepsWebsite: The Centre for Pain and Active Inference (PAIn) Research at HSUProfessor Dave Newell on FacebookWebsite: The ST School The ST School on FacebookAn Embodied Predictive Processing Theory of Pain ExperienceTherapeutic Alliance as Active Inference: The Role of Therapeutic Touch and SynchronyMASSAG model: Towards an integrative neuroscience framework linking emotional trauma, pain, and mechanisms of force-based manipulationsMark Miller on Predictive Processing - Todd Hargrove on SubstackPart 1 - Ep.272 with Dr. Bronnie Lennox Thompson and Ben Whybrow - available on the Sports Therapy Association YouTube channel and all popular podcast apps.
Part 3 Tues Feb 17th with special guest Dr. Rachel Dewar-Haggart, Postdoctoral Qualitative Researcher within the Medical Sociology & Health Experiences Research Group at the Nuffield Department of Primary Care Health Sciences, University of Oxford.
Part 4 Wed Feb 25th with special guest Dr. Rachel Zoffness, Pain scientist, International Speaker, Science Writer, with her new book “Tell Me Where It Hurts” coming out March 26th
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