The Substance is a 2024 satirical body horror film co-produced, written and directed by Coralie Fargeat. The film stars Demi Moore, Margaret Qualley and Dennis Quaid. An international co-production between the United Kingdom, the United States and France, its plot follows a fading celebrity (Moore) who decides to use a black market drug, a cell-replicating substance that temporarily creates a younger, better version of herself (Qualley), unknowingly giving herself horrifying side effects.The Substance premiered on 19 May 2024 at the 77th Cannes Film Festival, and was selected to compete for the Palme d'Or in its main competition section, where Fargeat won Best Screenplay. The film was released theatrically in the United Kingdom and the United States by Mubi on 20 September 2024, and is scheduled to be released in France by Metropolitan Filmexport on 6 November 2024.

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