The Tox Lab

By The Tox LabScience

The Tox Lab episodes

December 16, 2024 Episode 8: Festive Poisons
Have you ever wondered how toxic your festive flora is? Does Nutmeg have a dark side?
In this week's episode, we discuss poinsettia, holly, and mistletoe to try and determine if they really are as toxic as we are all led to believe. We also talk about nutmeg and its potential for abuse.
We will be taking a break for a couple of weeks after this episode but will be back on the 6th of January.
Hope you all have a lovely festive season, and we will see you in 2025!
Go and check out our Instagram @the_tox_lab
Links to papers we have discussed:
Poinsiettia: https://www.sciencedirect.com/science/article/abs/pii/S0735675796900868?via%3Dihub
Holly: https://pmc.ncbi.nlm.nih.gov/articles/PMC3555592/
Mistletoe: https://www.sciencedirect.com/science/article/abs/pii/S0735675797901996?via%3Dihub
https://www.annemergmed.com/article/S0196-0644(86)80619-9/abstract
Nutmeg:https://pmc.ncbi.nlm.nih.gov/articles/PMC4057546/
https://www.sciencedirect.com/science/article/abs/pii/S0379073800003698
29 min
December 09, 2024 Episode 7: Truth or Bias - self reporting vs lab testing
In this week's episode we aim to answer the question: can people really be trusted to report their own drug use?
We discuss a paper by Wolfe et al. which looks at self-reported drug use compared to the results of laboratory testing from patients presenting to a london emergency department with acute drug toxicity.
Hope you enjoy!
Link to the paper we've discussed:
https://www.tandfonline.com/doi/full/10.1080/15563650.2024.2402070
23 min
December 02, 2024 Episode 6: Methanol Poisoning
In this week's episode, we discuss the methanol poisonings in Laos, and a paper by Doreen et al. which covers methanol poisoning from contaminated alcohol in Uganda in 2017.
Hope you enjoy!
Links to papers we have discussed:
https://pmc.ncbi.nlm.nih.gov/articles/PMC7204301/
14 min
November 25, 2024 Episode 5: Swedish poisonings and sauna deaths
In this week’s episode we discuss a paper by Linqvist et al. on Swedish poisoning deaths from 2000-2022 and a paper by Rhode et al. on sauna deaths in Sweden. Is there a link between carbon monoxide deaths and saunas?
Hope you enjoy!
Papers we have discussed:
https://onlinelibrary.wiley.com/doi/10.1111/bcpt.14097
https://journals.lww.com/amjforensicmedicine/abstract/2008/03000/sauna_deaths_in_sweden,_1992_2003.7.aspx
Find us on Instagram @the_tox_lab
20 min
November 18, 2024 Episode 4: Bromazolam and Desalkylgidazepam
In this week’s episode, we discuss a paper by Ellefsen et al. on Bromazolam detections in post-mortem cases in Travis County Texas, and a paper by Mérette et al. on Desalkylgidazepam detections in forensic investigations in British Columbia.
Hope you enjoy!
Papers we have discussed:
https://academic.oup.com/jat/advance-article-abstract/doi/10.1093/jat/bkae079/7756913?redirectedFrom=fulltext
https://academic.oup.com/jat/article/47/9/858/7270447?login=false
19 min
November 11, 2024 Episode 3: Psychedelics
In this week's episode, we discuss a paper by Kopra et al. covering psychedelic- related deaths in England, Wales and Northern Ireland over a 25 year period and a paper by Palamar et al. on 'shrooms' seizures in the US from 2017-2022. We also discuss a paper by Abrams et al. which talks about the different effects seen in spinal cord injury patients after serotonergic psychedelic use.
Hope you enjoy!
Links to papers we have discussed:
https://www.sciencedirect.com/science/article/pii/S0278584624002458?via%3Dihub
https://www.sciencedirect.com/science/article/abs/pii/S0376871624000073?via%3Dihub
https://www.liebertpub.com/doi/10.1089/neur.2023.0022
24 min
November 04, 2024 Episode 2: Semi-Synthetic Cannabinoids and N-Ethylhexedrone
In this week’s episode, we discuss the recently published ONS data on deaths related to drug poisonings in England and Wales in 2023. We also discuss a paper by Jørgensen et al. on semi-synthetic cannabinoids in cannabis products in Eastern a Denmark, and a case series by Lefeuvre et al. on N-Ethylhexedrone.
Hope you enjoy!
Links to the papers we have discussed:
https://www.ons.gov.uk/peoplepopulationandcommunity/birthsdeathsandmarriages/deaths/bulletins/deathsrelatedtodrugpoisoninginenglandandwales/2023registrations
https://onlinelibrary.wiley.com/doi/10.1111/1556-4029.15631
https://academic.oup.com/jat/article-abstract/48/7/507/7682083?redirectedFrom=fulltext
27 min
October 28, 2024 Episode 1: Nitazene and Xylazine
In this week’s episode we discuss the recent OHID report talking about synthetic opioid deaths in England. We also discuss a paper by Bedard et al. talking about Xylazine withdrawal in mice and its receptor binding activity, and a paper by Love et al. discussing how Xylazine alters opioid overdose patient’s outcomes.
Hope you enjoy!
Links to the papers we have discussed:
https://www.gov.uk/government/publications/deaths-linked-to-potent-synthetic-opioids/deaths-linked-to-potent-synthetic-opioids
https://www.tandfonline.com/doi/abs/10.1080/15563650.2022.2159427?ref=opioiddatalab.ghost.io
https://www.sciencedirect.com/science/article/pii/S2772392524000142#:~:text=A%20general%20assumption%20has%20been%20that%20due
28 min

About The Tox Lab

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The Tox Lab is a podcast dedicated to exploring the science of toxicology and its real-world implications. Each week we aim to break down complex research, investigate real-life cases, and discuss emerging trends in toxicology.