What is actually happening to our brains in midlife—and how much of what we're experiencing is connected to hormones?
This week on The Unapologetic MidLife Podcast, Mindi sits down with Dr. Jessica Lowe, aka Doctor Brain Barbie, a double board-certified neurologist and epileptologist who has built a massive online community by making complicated neurological information understandable, relatable, and actually interesting.
And yes—you can absolutely love pink, glitter, and femininity while also being a highly trained medical expert.
In this conversation, Dr. Lowe shares how she became "Doctor Brain Barbie," why she refuses to fit the stereotypical image of what a neurologist is supposed to look or act like, and what she has learned about navigating misinformation and criticism online.
Then we get into the brain.
Mindi and Dr. Lowe dive into the neurological changes women may experience during perimenopause and menopause, including brain fog, memory changes, migraines, sleep disruption, stress, mental health, and the impact of fluctuating hormones on the brain.
Dr. Lowe also brings a unique perspective to the conversation because she doesn't just treat migraine—she lives with chronic migraine herself.
They discuss why "the migraine brain does not like change," how hormonal fluctuations can influence migraine patterns, the role hormone therapy may play during menopause, and why sleep deserves far more attention when we're talking about cognitive and neurological health.
They also tackle one of the biggest fears women have when they suddenly can't remember a word, lose their train of thought, or walk into a room and have absolutely no idea why they're there:
Is this normal midlife brain fog—or something more serious?
This episode is about understanding what is happening inside your brain instead of automatically assuming every new symptom means you're "just getting older."
Because as Dr. Lowe reminds us:
"Your brain isn't betraying you."
And perhaps just as importantly:
"You can be girly and still be an expert."
IN THIS EPISODE
🧠 What happens to the female brain during perimenopause and menopause 🧠 Hormonal fluctuations and neurological symptoms 🧠 Why migraines can change during midlife 🧠 The relationship between estrogen, menopause, and migraine 🧠 Hormone therapy and migraine 🧠 Brain fog vs. signs that deserve further evaluation 🧠 Sleep disruption and cognitive function 🧠 Mental health and the midlife brain 🧠 Dr. Lowe's personal experience living with chronic migraine 🧠 Medical misinformation on social media 🧠 Why credible health information matters 🧠 Challenging stereotypes about femininity and intelligence 🧠 Why patients and healthcare providers need to work collaboratively
CONNECT WITH DR. JESSICA LOWE — DOCTOR BRAIN BARBIE
📸 Instagram: @doctorbrainbarbie 🎵 TikTok: @doctorbrainbarbie 🔗 Linktree: Doctor Brain Barbie
CONNECT WITH MINDI + THE UNAPOLOGETIC MIDLIFE PODCAST
🎙️ The Unapologetic MidLife Podcast 📸 Instagram: @Unapologetic_midlife 🎵 TikTok: The Unapologetic MidLife Podcast 📘 Facebook: The Unapologetic MidLife Podcast ▶️ YouTube: The Unapologetic MidLife Podcast ✍️ Substack: The Unapologetic MidLife 🌐 Website: The Unapologetic MidLife Podcast
Hosted by Mindi Lobuzzetta, LMHC
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DISCLAIMER: The information shared in this episode is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any medical or mental health condition. This podcast does not establish a physician-patient or therapist-client relationship. Always consult with your own qualified healthcare provider regarding your individual health, symptoms, medications, or treatment decisions.
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