The Yellow Emperor’s Classic of Internal Medicine, Chapter 12, explores regional variations in illness and treatment. Qibo, responding to the Yellow Emperor's inquiry, explains that geographical factors—climate, terrain, diet, and lifestyle—influence the types of diseases prevalent in each of five regions (East, West, North, South, and Center). He posits that optimal healing requires tailoring treatment to the specific regional characteristics and resultant disease patterns. This approach emphasizes the importance of understanding both the illness and its environmental context for effective treatment. The text highlights diverse therapeutic methods, including acupuncture, moxibustion, herbal remedies, and physical therapies, each suited to a specific region and its corresponding health issues.