In this episode of Inside the Lab, host Constantine Kanakis is joined by former ASCP president and Director of Transfusion Medicine at VCU Dr. Kimberly Sanford to discuss topics in transfusion medicine. This one-on-one conversation between two transfusion experts covers a wide variety of contemporary issues in transfusion medicine, including best practices in apheresis, logistical issues associated with pre-hospital transfusion services, and strategies for addressing blood shortages. Their conversation also touches on how to compassionately discuss problems with so-called “vaccine-negative blood” with patients in the context of recent legislation regarding this, and how transfusion experts can best ration limited blood supplies during periods of scarcity.