Iron is a mineral naturally found in the environment on Earth, within food sources and in all living organisms. A number of biochemical systems require this mineral and, in humans, the lack of iron results in anemia and a deficiency in hemoglobin—the protein responsible for supplying the body with oxygen. Anemia can also be caused by iron dysregulation. This occurs when iron damages the protein it should be safely stored in, such as ferritin, and then reacts in a toxic manner with surrounding cellular structures and organs. While iron is essential, the chemical properties of iron can make it a harmful substance if it is not tightly regulated.

“The very property of iron that makes it useful, its ability to accept or donate electrons, also gives it the ability to damage molecules and organelles via the Fenton reaction, in which iron reacts with hydrogen peroxide, leading to the formation of the highly reactive and toxic free radical, hydroxyl.”

Dennis Mangan (P. D. Mangan) is a clinical biochemist/microbiologist, researcher, author, health and fitness expert, and anti-aging specialist. In October of 2021, he authored a new theory article that positions iron as a potential driver of aging. This trending paper was published in Aging (Aging-US) Volume 13, Issue 19, and entitled, “Iron: an underrated factor in aging.”

Full blog - https://www.impactjournals.com/journals/blog/aging/trending-with-impact-is-iron-a-driver-of-aging/

Press Release - https://www.aging-us.com/news_room/iron-an-underrated-factor-in-aging

Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.203612

DOI - https://doi.org/10.18632/aging.203612

Full Text - https://www.aging-us.com/article/203612/text

Correspondence to: Dennis Mangan email: [email protected]

Keywords: iron, aging, oxidative stress, calorie restriction, plasma dilution

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

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