We take listener calls on the future of both state parties, the coronavirus outbreak at the State House, and increasingly dire warnings about gathering for Thanksgiving.

We check in with Massachusetts Congresswoman Ayanna Pressley on her legislative priorities for her second term, the ongoing tension between moderate and progressive Democrats, and how she's reflecting on our current moment.

Plus: We start the hour with Congresswoman Ayanna Pressley.

In addition to a new sense of hope, positive news around the vaccine trials has also raised a whole host of questions about vaccine safety, speed to market, availability of doses, and even whether people will actually get it.

Have you had one of those moments since this pandemic started when you just suddenly felt sad? Or maybe you've experienced the massive loss of someone you love? Claire Willis says grief varies widely by person, as does how we handle it.

Plus: When Pfizer and then Moderna announced efficacy rates of their vaccines during trials at 90 percent and higher, there was a new note of hope. The news also raised a whole host of questions around vaccine safety, availability of doses, and even whether people will take it.

Massachusetts Congresswoman Katherine Clark has made history: knocking out another piece of the glass ceiling as she ascends in the House's Democratic leadership.

We check in on how the city is handling the second wave of the pandemic and its prospects for a return to economic growth.

We take calls on how our listeners' plans have turned out: What sacrifices will you be making this Thanksgiving? What traditions will you miss, and what will you be happy to skip this year?