Pathologists and laboratory staff in various practice settings have experienced severe challenges and stresses secondary to the COVID-19 pandemic. This CAPcast features an audio recording of a virtual roundtable discussion about pathologist wellness and resilience in the face of burnout, which was hosted by the CAP’s Practice Management Committee earlier in 2021. Moderated by Dr. Karim Sirgi, panelists include Dr. Gina Ann Drobena, who is a pathologist at the University of Arkansas for Medical Sciences and Dr. Judy Melinek, CEO of Pathology Expert.