Aging published this trending editorial on May 20, 2021, entitled, “When aging switches on Alzheimer’s” by researchers from the Department of Biomedical Engineering, MIND Institute, Center for Neurobiology of Learning and Memory, University of California, Irvine, CA.

In the paper, the researchers discuss the effects of oxidative stress in aging and Alzheimer’s disease. In short, age-related oxidative stress launches a global shift in the epigenetic landscape, and drives metabolic and energetic “switches.” The researchers point out that these "switches" highlight potential epigenetic targets for the treatment of Alzheimer’s disease.

To date, this study has generated an Altmetric Attention Score of 22. The Altmetric Attention Score provides an at-a-glance indication of the volume and type of online attention the research has received.

Top Aging publications rated by Altmetric Attention Score - https://www.aging-us.com/news_room/altmetric

Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.203085

DOI - https://doi.org/10.18632/aging.203085

Full text - https://www.aging-us.com/article/203085/pdf (PDF Download)

Correspondence to: Gregory J. Brewer email: [email protected]

Keywords: Alzheimer’s disease, NAD+/NADH, oxidative shift, mitochondrial impairment, neuroinflammation, aging

About Aging

Launched in 2009, Aging publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

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