SHR # 2454 :: When Intermittent Fasting Backfires - Joel Greene - We first talked about IF back in 2007 on SHR. Fast-forward to today and the mainstream is now promoting IF is the Holy Grail of dietary approaches that promises improved weight loss, age reversal, insulin sensitivity, immune function and much more. But is it really? Like every dietary fad people can take it too far. Is there a downside to IF? Is it wise to do indefinitely? What happens when it backfires? What about longer fasts? These and many other questions will be discussed.