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Beyond the Thyroid – Episode 46: When T3 Doesn’t Work — How to Dose Thyroid Medication Correctly (Part 2)

In Part 2 of this T3 deep-dive, Dr. Dana Gibbs explains why T3 thyroid medication often fails because of dosing strategy—not because T3 is the wrong medication.

Building on Episode 45, Dr. Gibbs walks through the most common mistakes clinicians and patients make when starting or adjusting T3-containing medications. She explains why how you dose matters just as much as what you prescribe, and why mismatched T4:T3 ratios, cortisol dysregulation, and insulin resistance can derail even the best treatment plans.

You’ll learn how proper dosing, timing, and lab interpretation can transform T3 from a medication patients fear into one that works reliably and safely. Dr. Gibbs also revisits the case of a patient named Barbara, showing how correcting dosing strategy led to real, sustained improvement.

This episode is essential listening for anyone who has tried T3 and felt worse—or wants to get it right the first time.

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Episode Highlights

00:00 – Introduction and Episode Overview
00:43 – Why T3 Problems Are Usually Dosing Problems
02:23 – How to Dose T3 Correctly
06:02 – Common Mistakes with T3 and T4 Ratios
21:09 – Cortisol, Insulin Resistance, and T3
25:21 – Case Study: Barbara’s Journey
25:50 – Steps to Optimize Thyroid Treatment
35:54 – Final Thoughts and Resources

With the right system, T3 can be one of the most effective tools in thyroid care.

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✉️ Email Dr. Gibbs at [email protected] or visit https://www.danagibbsmd.com/ for more information.


Thank you so much for listening! Tune in on the next episode.


The medical information provided in this episode is intended for informational purposes only and should not be construed as medical advice. Always consult a qualified healthcare provider regarding any medical questions or concerns.