For most of human history, people went about their daily lives with a worm or two (or fifty) in their guts. Only in the past century, with pharmaceuticals and sanitation practices, have we made significant strides towards deworming the whole of humanity. And that’s typically been thought of as a good thing, because having too many worms in your body can–quite literally–suck the life out of you.

But is it possible to have… too few worms? Science wonders if deworming ourselves has actually led to an increase in certain chronic diseases. On this episode, we dive into Necator americanus, a.k.a. the American Hookworm, and its mysterious relationship with each of us.

We trace the hookworm’s 118-year journey from a demonized economic depressant, to its use as a desperate D.I.Y. immunosuppressant, to its potential as a medical treatment for a number of chronic diseases, everything from asthma to MS.

We’re bringing back two stories  from our 2009 episode Parasites plus new research on hookworms and autoimmune diseases, reported by Molly Webster

Special thanks to Ethan Hein for the use of his remix of Mozart's Piano Concerto No. 21. Plus, Doris Pierce, and Dan and Alice Hadley.

EPISODE CREDITS: 

Reported by - Pat Walters and Molly Webster

Produced by - Matt Kielty

with help from - Rebecca Rand

Fact-checking by - Diane A. Kelly

and Edited by  - Arianne Wack

EPISODE CITATIONS:

Articles - 

Effect of experimental hookworm infection on insulin resistance in people at risk of type 2 diabetes (https://pubmed.ncbi.nlm.nih.gov/37495576/) by Giacomin PR et al. Nat Commun. 2023 Jul 26

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