Can ozempic and the other popular GLP1 agonist medications cause kidney stones? Melanie gives an update on with the research says, as well as her advice for people with kidney stones who want to start one of these medications.

References:

Feghali K, Li X, Maalouf NM. Changes in 24-Hour Urine Chemistry in Patients with Nephrolithiasis during Weight Loss with GLP-1 Peptide Therapies: Kidney360. 5(11):p.1706-1712.

Zhao, Kelley; Shkolnik, Brian; Lu, Jennifer; Miller, Joshua; Schulsinger, David. MP10-05 LITHOPROTECTIVE EFFECT OF GLP-1 AGONISTS IN DIABETIC STONE FORMERS. The Journal of Urology 209(Supplement 4):p e115, April 2023. 

Xie Y, Choi T, Al-Aly Z. Mapping the effectiveness and risks of GLP-1 receptor agonists. Nat Med. 2025;31(3):951-962. 

Hsi R, Best S, Oerline M, et al. MP26-20 CHANGES IN 24-HOUR URINE PARAMETERS ASSOCIATED WITH SGLT-2 INHIBITORS AND GLP-1 RECEPTOR AGONISTS. Journal of Urology. 2024;211(5S):e421. 

Schaub JA, Oerline MK, Crivelli JJ, et al. The Impact of SGLT2 Inhibitors and GLP-1 Receptor Agonists on 24-hour Urine Parameters: A Retrospective Cohort Study. Kidney360. Published online February 25, 2025:10.34067/KID.0000000728. 

 

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All information in this podcast is meant for educational purposes only and should not be used in place of advice from a medical professional.