This episode relates the history of the new field of "skeletal editing" of molecules. While there have been a few known reactions of this type since the very late 1800s, the general system was unknown till the 21st century, beginning with Marcos Suero. We add to the mix Mark Levin and Guangbin Dong, talk of what precisely this type of chemistry does, and relate the wish-list of chemists of all the wonderful things that scientists would like in skeletal editing.

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