In this solo podcast episode, Dr. Mike Hart delves into the intricacies of insulin resistance, a prevalent yet misunderstood condition. The episode covers the fundamental role of insulin, what happens during insulin resistance, and its linkage to various diseases like diabetes and heart disease. It includes a detailed discussion on how to measure insulin resistance using markers like triglyceride to HDL ratio, fasting insulin, fasting glucose, and hemoglobin A1c. Dr. Hart also explains the significance of advanced glycation end products (AGEs) and how they contribute to aging and diabetes. Practical tips on improving insulin sensitivity through diet, exercise, and supplements such as fiber, mulberry leaf extract, and berberine are provided. Additional considerations for managing blood sugar levels and preventing insulin resistance are also discussed.

Links:

Fasting Insulin Test: https://medlineplus.gov/lab-tests/insulin-in-blood/

Fructosamine Test: https://medlineplus.gov/lab-tests/insulin-in-blood/

Carnosine: https://examine.com/supplements/carnosine/?show_conditions=true

P5P (Pyridoxal-5-Phosphate): https://examine.com/supplements/vitamin-b6/?show_conditions=true

Show Notes:

00:00 Welcome back to the Hart2Heart Podcast with Dr. Mike Hart

00:56 Understanding Insulin and Insulin Resistance

03:02 Markers and Tests for Insulin Resistance

11:30 Advanced Glycation End Products (AGEs)

14:16 Exercise and Insulin Sensitivity

14:53 "Exercise keeps your body insulin sensitive for up to 48 hours — not just two."

16:21 Nutritional Strategies for Blood Sugar Control

20:59 Supplements and Medications for Blood Sugar Management

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The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to

cutting through the noise and uncovering the most effective strategies for optimizing health,

longevity, and peak performance. This podcast dives deep into evidence-based approaches to

hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise

protocols, leveraging sunlight light, and de-prescribing pharmaceuticals—using medications only when absolutely necessary.

Beyond health science, we tackle the intersection of public health and politics, exposing how

policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being.

Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary

(Commissioner of the Food and Drug Administration (FDA) and high-profile names such as

Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen).

If you're ready to take control of your health and performance, this is the podcast for you. We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.

Connect on social with Dr. Mike Hart:

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