Ticks pose a significant health risk to companion animals, both as blood-feeding parasites and as vectors for numerous pathogens. Over the past few decades, tick populations have expanded and intensified due to factors such as increased globalization, greater movement of humans and animals, and climate change. In the United States, common tick species—including the blacklegged tick, lone star tick, American dog tick, and brown dog tick—have the potential to transmit a range of bacterial, protozoal, and viral pathogens.

Serological data indicate that tick-borne pathogens are a persistent challenge for dogs, with US canines frequently testing positive for agents of anaplasmosis, Lyme disease, and ehrlichiosis. Many of these same ticks and pathogens also pose a public health risk, as the tick species that commonly bite dogs can also transmit these same pathogens to humans. As a result, dogs can serve as valuable sentinels for tick-borne disease risks of their human families.

Despite awareness of the risks ticks pose to pets, ticks are often and easily overlooked. Given that ticks are a year-round threat in most regions, annual testing and the routine use of fast-acting tick control products play a critical role in protecting pet health by killing ticks and reducing pathogen transmission risk.

Indications: Credelio Quattro (lotilaner, moxidectin, praziquantel, and pyrantel chewable tablets) is indicated for the prevention of heartworm disease caused by Dirofilaria immitis and for the treatment and control of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina), hookworm (fourth stage larvae, immature adult, and adult Ancylostoma caninum and adult Uncinaria stenocephala), and tapeworm (Dipylidium caninum, Taenia pisiformis, and Echinococcus granulosus) infections. Credelio Quattro kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations [Amblyomma americanum (lone star tick), Dermacentor variabilis (American dog tick), Ixodes scapularis (black-legged tick), and Rhipicephalus sanguineus (brown dog tick)] for one month in dogs and puppies 8 weeks of age and older and weighing 3.3 pounds or greater.

Important Safety Information: Lotilaner, an ingredient in Credelio Quattro, belongs to the isoxazoline class and has been associated with neurologic adverse reactions like tremors, ataxia, and seizures even in dogs without a history of seizures. Use with caution in dogs with a history of seizures or neurologic disorders. Dogs should be tested for existing heartworm infections before Credelio Quattro administration as it is not effective against adult D. immitis. The safe use in breeding, pregnant, or lactating dogs has not been evaluated. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea. For full prescribing information see the Credelio Quattro package insert.

Credelio Quattro Label