The San Francisco 49ers held their final practice Wednesday in Santa Clara ahead of their international flight that evening to Melbourne, Australia. For the first time all offseason, star defensive end Nick Bosa and tight end George Kittle were present and fully participating together. On "49ers Talk," Matt Maiocco and Jennifer Lee Chan discuss how the pair of veteran superstars can navigate the long journey down under with a clean bill of health. Later, quarterback Brock Purdy opens up to Matt about his maturation as a leader, a family-man, and his excitement for the upcoming season.

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It's roster cutdown day, and the San Francisco 49ers had to make some tough decisions as they whittled their squad down from 90 to 53 players. On this episode of "49ers Talk," Matt Maiocco and Jennifer Lee Chan provide in-depth analysis of the 49ers' initial 53-man roster and what these decisions mean for the upcoming season.

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The 49ers wrapped up their preseason with a 18-12 touchdown-less win over the Las Vegas Raiders Thursday at Allegiant Stadium. Next up is the difficult task of finalizing the 53-man roster by Sunday afternoon. On "49ers Talk,' Matt Maiocco and Jennifer Lee Chan discuss which position-group competitions remain and any late risers who could challenge for a roster spot with injuries undoubtedly playing a major role in final decisions.

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On this episode of "49ers Talk," Matt Maiocco and Jennifer Lee Chan discuss the fallout after San Francisco's principal owner, Jed York, entered no-contest pleas on two misdemeanor charges Monday morning in Ohio. Could this offseason turmoil leak into the 49ers' on-field results? Then, the duo welcomes legendary broadcaster Greg Papa on the return of "Ask Papa" as NBC Sports Bay Area unveils its new studio and game day team. Later, 49ers offensive lineman Enrique Cruz Jr. rounds out the episode in the final installment of "Meet the Rookies."

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(0:00) 49ers owner Jed York arrested

(The David Benzer Strike Out Fear Foundation, a 501(c)(3)nonprofit, has established a GoFundMe campaign to help ease the financial burden of Greg’s long recovery period. Funds will be used to assist with everyday living expenses while Greg is unable to work, and medical out-of-pocket expenses not fully covered by insurance including medical co-pays, uncovered medications, and home healthcare. Those wishing to support Greg can visit: support.strikeoutfear.org/helpgregpapabeatcancer)

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The 49ers received a major roster boost ahead of their preseason finale, as star tight end George Kittle was activated off the PUP list and running back Christian McCaffrey rejoined the fray after speculation about his "tightness." On "49ers Talk," Matt Maiocco and Jennifer Lee Chan discuss just how important the return of both of these veterans is, and if Kittle could very well play Week 1 in Australia. Later, we hear from versatile rookie linebacker Jaden Dugger, who sits down with Matt on the seventh edition of Meet the Rookies.

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Despite an uneven week of practice leading up to Thursday's game in Los Angeles, the 49ers responded with an emphatic 41-17 thumping of the Chargers at "Levi's South" in their second preseason game. Rookies De'Zhaun Stribling, Kaelon Black and Romello Height made impressive early plays that set the tone for the rest of the matchup. Players on the bubble to make the 53-man roster -- notably Jacob Cowing -- also stepped up with some highlights later on, particularly on special teams. On "49ers Talk," Matt Maiocco and Jennifer Lee Chan discuss how the 49ers bounced back from their bumpy joint practice earlier in the week to beat Jim Harbaugh and the Chargers.

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On "49ers Talk," Matt Maiocco and Jennifer Lee Chan discuss how the 49ers were challenged on both sides of the ball in their joint practice with the Los Angeles Chargers on Tuesday in El Segundo. As Justin Herbert found holes in San Francisco's secondary, Brock Purdy and the 49ers' offense seemed disjointed. On a positive note, coach Kyle Shanahan eased contract concerns about Christian McCaffrey, and rookie Kaelon Black returned to the backfield. Later, Jennifer sits down with cornerback Ephesians Prysock in the sixth edition of Meet the Rookies.

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(1:00) 49ers will move to a new practice facility soon

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Ahead of Week 2 of San Francisco's preseason, star tight end George Kittle took to the podium to update reporters on his recovery from a torn right Achilles tendon suffered during last season's NFL playoffs. Kittle remains confident he won't start the season on the PUP list and stated he could be back for the 49ers' regular-season opener in Australia. On "49ers Talk," Matt Maiocco and Jennifer Lee Chan discuss Kittle's progress and look forward to San Francisco's second preseason game against Jim Harbaugh and the Los Angeles Chargers. Later, Matt sits down with rookie Carver Willis in the fifth edition of Meet the Rookies.

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(1:00) Upcoming joint practices, preseason game vs. Jim Harbaugh and the Chargers

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On "49ers Talk," Matt Maiocco and Jennifer Lee Chan discuss San Francisco's preseason debut against the Tennesee Titans. Despite the 49ers' 19-13 loss, San Francisco's 2026 draft class made a huge impact, including wide receiver De'Zhaun Stribling, who stole the show early and often. On the defensive side, rookies Jaden Duggar and Gracen Halton made their presence felt while second-year linebacker Nick Martin also impressed.

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(0:00) Biggest takeaways from Preseason Week 1 game: 2026 draft class performance

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On "49ers Talk," Matt Maiocco and Jennifer Lee Chan discuss how early dustups in the 49ers' joint practice with the Tennessee Titans gave way to a productive session on both sides of the ball. Fred Warner and the 49ers' defense limited quarterback Cam Ward and the Titans' offense, while Brock Purdy effectively moved the offense. Matt and Jennifer break down the best plays, the biggest battles and provide the latest injury updates. Plus, Matt sits down with rookie Kaelon Black in the fourth edition of Meet the Rookies.

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(0:00) Titans joint practice chippy from opening whistle

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