Quick summaries of our last 10 articles, perfect for busy people! 

61. Safety of Buprenorphine/Naloxone vs. Buprenorphine in Pregnancy 

Straub L, et al. Comparative Safety of In Utero Exposure to Buprenorphine Combined With Naloxone vs Buprenorphine Alone. JAMA. 2024 Sep 10;332(10):805-816.  

62. Naltrexone Pills vs Injections for Alcohol Use Disorder 

Magane KM, et al. Oral vs Extended-Release Injectable Naltrexone for Hospitalized Patients With Alcohol Use Disorder: A Randomized Clinical Trial. JAMA Intern Med. 2025 Jun 1;185(6):635-645. 

63. Buprenorphine Dose and Neonatal Opioid Withdrawal 

Marc B, et al. Is buprenorphine maternal dose associated with neonatal opioid withdrawal syndrome severity? Am J Addict. 2025 Jan;34(1):15-20. 

64. Screen Addiction and Suicide 

Xiao Y, et al. Addictive Screen Use Trajectories and Suicidal Behaviors, Suicidal Ideation, and Mental Health in US Youths. JAMA. 2025;334(3):219–228. 

65. Varenicline and Bupropion for Alcohol Use Disorder 

Söderpalm B, et al.  Efficacy and safety of varenicline and bupropion, in combination and alone, for alcohol use disorder: a randomized, double-blind, placebo-controlled multicentre trial. Lancet Reg Health Eur. 2025 May 13;54:101310.  

66. Smoking in Recovery 

Parks MJ, , et al. Cigarette Smoking During Recovery From Substance Use Disorders. JAMA Psychiatry. Published online August 13, 2025. 

67. Rapid-Start Injectable Buprenorphine 

Waters RC, et al. Injectable-Only Overlapping Buprenorphine Starting Protocol in a Low-Threshold Setting. JAMA Netw Open. 2025;8(8):e2527016.   

68. Behavioral Treatments as an Adjunct to Buprenorphine 

McHugh RK, et al. Behavioral Therapy as an Adjunct to Buprenorphine Treatment for Opioid Use Disorder: A Secondary Analysis of 4 Randomized Clinical Trials. JAMA Netw Open. 2025 Aug 1;8(8):e2528529. 

69. Cytisinicline for Smoking Cessation 

Rigotti NA, et al. Cytisinicline for Smoking Cessation: The ORCA Phase 3 Replication Randomized Clinical Trial. JAMA Intern Med. 2025 Jun 1;185(6):648-655. 

70. Prescription Stimulant Misuse 

Han B, Jones CM, Volkow ND, et al. Prescription Stimulant Use, Misuse, and Use Disorder Among US Adults Aged 18 to 64 Years. JAMA Psychiatry. 2025;82(6):572–581. 

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No CME for this episode, but other episodes offer category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To learn more about opportunities in addiction medicine, visit MI CARES. 

CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/  

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Original theme music: composed and performed by Benjamin Kennedy 

Audio editing: Michael Bonanno 

Executive producer: Dr. Patrick Beeman 

A podcast from Ars Longa Media 

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This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice.  

The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group. 

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Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities.

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