In episode 68 we discuss an article about adding behavioral treatments to buprenorphine for opioid use disorder.

McHugh RK, et al. Behavioral Therapy as an Adjunct to Buprenorphine Treatment for Opioid Use Disorder: A Secondary Analysis of 4 Randomized Clinical Trials. JAMA Netw Open. 2025 Aug 1;8(8):e2528529.

We also discuss online gambling addiction, and neuroanatomy that predisposes adolescents to addiction.

Stat News: Head of addiction medicine society warns of treatment cuts and rising threat of gambling

Miller AP, et al. Neuroanatomical Variability and Substance Use Initiation in Late Childhood and Early Adolescence.  JAMA Netw Open. 2024;7(12):e2452027.

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This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit MI CARES.

CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/

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This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice.

The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group.

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Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities.

Learn more about your ad choices. Visit megaphone.fm/adchoices

In episode 67 we discuss an article about starting buprenorphine injectables without stopping fentanyl or going into opioid withdrawal. 

Waters RC, et al. Injectable-Only Overlapping Buprenorphine Starting Protocol in a Low-Threshold Setting. JAMA Netw Open. 2025;8(8):e2527016.   

We also discuss over-the-counter magic mushrooms and banning cigarette filters.  

JAMA Network Open: Active Constituents of Psilocybin Mushroom Edibles 

The Conversation: Cigarette filters do nothing for smokers’ health and just create plastic pollution – they should be banned 

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This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit MI CARES. 

CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/  

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This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice.  

The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group. 

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Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities.

Learn more about your ad choices. Visit megaphone.fm/adchoices

In episode 66 we discuss an article about smoking during substance use disorder recovery. 

Parks MJ, Blanco C, Creamer MR, et al. Cigarette Smoking During Recovery From Substance Use Disorders. JAMA Psychiatry. Published online August 13, 2025.  

We also discuss how the White House is pressuring the FDA to fast-track nicotine products and shenanigans regarding alcohol in the upcoming FDA dietary guidelines. 

Reuters: US FDA to fast-track nicotine pouch reviews amid White House pressure 

Vox: RFK Jr. and the White House buried a major study on alcohol and cancer. Here’s what it shows. 

Draft Report: Scientific Findings of the Alcohol Intake & Health Study for Public Comment 

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This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit MI CARES. 

CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/  

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Original theme music: composed and performed by Benjamin Kennedy 

Audio editing: Michael Bonanno 

Executive producer: Dr. Patrick Beeman 

A podcast from Ars Longa Media 

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This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice.  

The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group. 

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Email: [email protected]  

Facebook: @AddictionMedJC 

Facebook Group: Addiction Medicine Journal Club 

Instagram: @AddictionMedJC  

Threads: @AddictionMedJC 

YouTube: addictionmedicinejournalclub  

Twitter/X: @AddictionMedJC   

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Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities.

Learn more about your ad choices. Visit megaphone.fm/adchoices

In episode 65 we discuss varenicline and bupropion for alcohol use disorder. 

Söderpalm B, Lidö H, Franck J, Håkansson A, Lindqvist D, Heilig M, Guterstam J, Samuelson M, Askerup B, Wallmark-Nilsson C, de Bejczy A. Efficacy and safety of varenicline and bupropion, in combination and alone, for alcohol use disorder: a randomized, double-blind, placebo-controlled multicentre trial. Lancet Reg Health Eur. 2025 May 13;54:101310.  

We also discuss medical marijuana for anxiety in Pennsylvania, and RFK’s embrace of psychedelic therapy. 

Annals of Internal Medicine: Medical Cannabis Certifications After Pennsylvania Added Anxiety Disorders as a Qualifying Condition 

Annals of Internal Medicine: High-Concentration Delta-9-Tetrahydrocannabinol Cannabis Products and Mental Health Outcomes: A Systematic Review 

MedPageToday: Will RFK Jr.'s Push for Psychedelic Therapy Help or Hamper the Emerging Field? 

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This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit MI CARES. 

CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/  

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This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice.  

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The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group. 

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Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities.

Learn more about your ad choices. Visit megaphone.fm/adchoices

In episode 64 we discuss an article about addictive screen use and suicide. 

Xiao Y, Meng Y, Brown TT, Keyes KM, Mann JJ. Addictive Screen Use Trajectories and Suicidal Behaviors, Suicidal Ideation, and Mental Health in US Youths. JAMA. 2025;334(3):219–228.  

We also discuss the impact of the first 100 days of the Trump administration on addiction treatment, and the DEA scheduling of 7-OH (hydroxymitrigynine). 

Journal of Addiction Medicine: The First 100 Days: The Trump Administration and Changes to Addiction Policy 

FDA: FDA Takes Steps to Restrict 7-OH Opioid Products Threatening American Consumers 

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This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit MI CARES. 

CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/  

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This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice.  

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The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group. 

--- 

Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities. 

Learn more about your ad choices. Visit megaphone.fm/adchoices

Quick summaries of articles 51-60. Enjoy!

51. Fun Activities and Recovery Acuff, S. F., et al. A brief measure of non-drug reinforcement: Association with treatment outcomes during initial substance use recovery. Drug and Alcohol Dependence, 256, 111092.

53. Methadone Vs. Buprenorphine

Nosyk B, Et al. Buprenorphine/Naloxone vs Methadone for the Treatment of Opioid Use Disorder. JAMA. 2024 Oct 17.

54. High Daily Doses of Buprenorphine

Axeen S, et al. Association of Daily Doses of Buprenorphine With Urgent Health Care Utilization. JAMA Netw Open. 2024 Sep 3;7(9):e2435478.

55. How Buprenorphine Works in Pregnancy

Caritis, Steve N. MD; et al. A Pharmacologic Evaluation of Buprenorphine in Pregnancy and the Postpartum Period. Journal of Addiction Medicine ():10.1097/ADM.0000000000001380, September 2, 2024.

56. How Many Quite Attempts Does It Take?

Fontes RM, et al. Beyond the first try: How many quit attempts are necessary to achieve substance use cessation? Drug Alcohol Depend. 2024 Dec 8;267:112525.

57. What is Recovery?

Zemore SE, et al. Understanding the Shared Meaning of Recovery From Substance Use Disorders: New Findings From the What is Recovery? Study. Subst Abuse. 2023 Sep 15;17:11782218231199372.

58. Semaglutide for Alcohol Use Disorder (The RCT)

Hendershot CS, et al. Once-Weekly Semaglutide in Adults With Alcohol Use Disorder: A Randomized Clinical Trial. JAMA Psychiatry. 2025 Feb 12:e244789.

Suen LW, et al. Outpatient Low-Dose Initiation of Buprenorphine for People Using Fentanyl. JAMA Netw Open. 2025 Jan 2;8(1):e2456253.

60. Lisdexamfetamine for methamphetamine use disorder

Ezard N, et al LiMA Investigator Group. Lisdexamfetamine in the treatment of methamphetamine dependence: A

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This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit

CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/

---

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This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice.

The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group.

---

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Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the

Learn more about your ad choices. Visit megaphone.fm/adchoices

PSAM Review (Page 6):

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Some of Our Favorite Addiction Medicine Resources:

Email alerts 

Google Alerts 

Evidence Alerts 

Email newsletters 

Recovery Research Institute 

ASAM weekly (with an associated podcast!) 

Alcohol, Drugs, and Health: Current Evidence 

Podcasts 

The Curbsiders Addiction Medicine Podcast 

Addiction Medicine Made Easy

The Addiction Medicine Journal Club

Online learning modules 

Providers Clinical Support System (PCSS) 

ASAM eLearning 

Journals  

The Journal of Addiction Medicine 

JAMA Network Open, Substance Use and Addiction Medicine 

Substance Use and Addiction Journal 

Conferences 

Pennsylvania Society of Addiction Medicine 

American Society of Addiction Medicine 

American Academy of Addiction Psychiatry  

This podcast episode does not offer CME, but other episodes do.

CME:

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Original theme music: composed and performed by Benjamin Kennedy

Audio editing: Michael Bonanno

Executive producer: Dr. Patrick Beeman

A podcast from Ars Longa Media

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This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice.

The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group.

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Addiction

Learn more about your ad choices. Visit megaphone.fm/adchoices

In episode 63 we discuss the association between buprenorphine dose and neonatal opioid withdrawal syndrome.

Marc B, Marion D, François B, Lakshmipriya L. Is buprenorphine maternal dose associated with neonatal opioid withdrawal syndrome severity? Am J Addict. 2025 Jan;34(1):15-20.

We also discuss private equity in health care and nitrous oxide (Galaxy Gas).

AMA Journal of Ethics: Is Pursuing Profit Commensurable With Providing Good Health Care?

David T. Zhu: presentation on private equity at the 2025 From Research to Recovery Conference.

Smithsonian Magazine: The Long, Strange History of Nitrous Oxide, a Popular Drug Users Have Been Inhaling for Hundreds of Years

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This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit MI CARES.

CME:

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This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice.

The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group.

Addiction Medicine Journal Club is intended for educational purposes

Learn more about your ad choices. Visit megaphone.fm/adchoices

In episode 62 we discuss the article “Oral vs Extended-Release Injectable Naltrexone for Hospitalized Patients with Alcohol Use Disorder.” 

Magane KM, et al. Oral vs Extended-Release Injectable Naltrexone for Hospitalized Patients With Alcohol Use Disorder: A Randomized Clinical Trial. JAMA Intern Med. 2025 Jun 1;185(6):635-645.  

We also discuss reduced overdose deaths and changes in buprenorphine labelling to include higher doses. 

NPR: Drug deaths plummet among young Americans as fentanyl carnage eases 

Federal Register: Modifications to Labeling of Buprenorphine-Containing Transmucosal Products for the Treatment of Opioid Dependence 

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This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit MI CARES. 

CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/ 

--- 

Original theme music: composed and performed by Benjamin Kennedy 

Audio editing: Michael Bonanno 

Executive producer: Dr. Patrick Beeman 

A podcast from Ars Longa Media 

--- 

This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice.  

The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group. 

Email: [email protected]  

Facebook: @AddictionMedJC 

Facebook Group: Addiction Medicine Journal Club 

Instagram: @AddictionMedJC  

Threads: @AddictionMedJC 

YouTube: addictionmedicinejournalclub  

Twitter/X: @AddictionMedJC   

Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities.

Learn more about your ad choices. Visit megaphone.fm/adchoices

In episode 61 we discuss pregnancy outcomes with bup/nlx compared to bup alone.

Straub L, et al. Comparative Safety of In Utero Exposure to Buprenorphine Combined With Naloxone vs Buprenorphine Alone. JAMA. 2024 Sep 10;332(10):805-816. doi: 10.1001/jama.2024.11501.

We also discuss the elimination of SAMHSA and methamphetamine-related deaths.

STAT News: Trump’s mental health and addiction problem

New York Times: As Fentanyl Deaths Slow, Meth Comes for Maine

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This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit MI CARES.

CME:

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This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice.

The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group.

Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities.

Learn more about your ad choices. Visit megaphone.fm/adchoices