In this episode we review 4 more practice changing articles with real-life case studies. 

Söderpalm B, Et al. Efficacy and safety of varenicline and bupropion, in combination and alone, for alcohol use disorder: a randomized, double-blind, placebo-controlled multicentre trial. Lancet Reg Health Eur. 2025 May 13;54:101310.   

Hendershot CS, Et al. Once-Weekly Semaglutide in Adults With Alcohol Use Disorder: A Randomized Clinical Trial. JAMA Psychiatry. 2025 Feb 12:e244789.   

Rigotti NA, et al. Cytisinicline for Smoking Cessation: The ORCA Phase 3 Replication Randomized Clinical Trial. JAMA Intern Med. 2025 Jun 1;185(6):648-655.   

Parks MJ, et al. Cigarette Smoking During Recovery From Substance Use Disorders. JAMA Psychiatry. Published online August 13, 2025. 

Thank you to the Pennsylvania Society of Addiction Medicine! 

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This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit MI CARES. 

CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/  

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This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice.  

The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group. 

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Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities. 

Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode we review 4 practice changing articles with real-life case studies. 

Coughlin LN, Et al. Contingency Management for Stimulant Use Disorder and Association With Mortality: A Cohort Study. Am J Psychiatry. 2025 Nov 1;182(11):1016-1023.   

Shiwach R, Et al. Rapid vs Standard Induction to Injectable Extended-Release Buprenorphine: A Randomized Clinical Trial. JAMA Netw Open. 2025;8(10):e2537319.   

Nosyk B, Et al. Buprenorphine/Naloxone vs Methadone for the Treatment of Opioid Use Disorder. JAMA. 2024 Oct 17.   

McHugh RK, et al. Behavioral Therapy as an Adjunct to Buprenorphine Treatment for Opioid Use Disorder: A Secondary Analysis of 4 Randomized Clinical Trials. JAMA Netw Open. 2025 Aug 1;8(8):e2528529. 

Thank you to the Pennsylvania Society of Addiction Medicine! 

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This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit MI CARES. 

CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/  

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This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice.  

The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group. 

--- 

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Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities. 

Learn more about your ad choices. Visit megaphone.fm/adchoices

In episode 73 we discuss the risk of long-term opioid use after an initial opioid prescription. 

Smith AM, Shah A, Martin BC. An updated view on the influence of initial opioid prescription characteristics on long-term opioid use among opioid naïve patients. Drug Alcohol Depend. 2024 Dec 1;265:112463.  

We also discuss alcohol’s place in the new dietary guidelines, and Canada’s drug decriminalization project. 

The White House:  Press briefing on the new dietary guidelines (Dr. Oz’s remarks start at 30:54) 

FDA: Dietary Guidelines (old and new) 

CityNews: B.C. to end drug decriminalization project, after ‘challenging’ three-year-experiment 

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This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit MI CARES. 

CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/  

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This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice.  

The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group. 

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Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities.

Learn more about your ad choices. Visit megaphone.fm/adchoices

In episode 72 we discuss a telemedicine protocol for outpatient symptom-triggered alcohol withdrawal management. 

Sloan ME, Ngoy A, Xiao KB, Barker B, Buckley L, Fodor M, Hardy K, Hendershot CS, Kahan M, La Fleur S, Le Foll B, Manicone M, Sanches M, Simpkin E, Quilty LC, Wyman J, Tang VM, Bozinoff N. Symptom-Triggered Alcohol Withdrawal Management Delivered Over Telemedicine. J Addict Med. 2025 Nov-Dec 01;19(6):708-715.  

We also discuss Trump Administration actions that facilitate addiction, including the cancellation of SAMHSA grants, loosening restrictions and regulations on alcohol, cannabis and psychedelics, and the pardoning of drug kingpins. 

ASAM: ASAM Statement on Marijuana Rescheduling Executive Order 

Complex: Here's The Drug Dealers Donald Trump Has Pardoned 

NPR: Trump administration sends letter wiping out addiction, mental health grants 

NPR: Trump administration rolls back $2 billion mental health, addiction grant cuts 

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This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit MI CARES. 

CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/  

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This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice.  

The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group. 

--- 

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Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities. 

Learn more about your ad choices. Visit megaphone.fm/adchoices

In episode 71 we discuss dental problems caused by buprenorphine. 

Tuan WJ, Clebak KT, Jawadi E, Snyder J, Zgierska AE. Risk of Oral Health Problems in Adults With Opioid Use Disorder Treated With Transmucosal Buprenorphine. J Addict Med. 2025 Sep-Oct 01;19(5):529-535.  

We also discuss over-the-counter naltrexone and what RFK said at his senate confirmation hearing about substance use disorder. 

JAMA Psychiatry: Over-the-Counter Naltrexone to Address Unhealthy Alcohol Use 

NPR: RFK Jr. says he'll fix the overdose crisis. Critics say his plan is risky 

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This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit MI CARES. 

CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/  

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This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice.  

The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group. 

--- 

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Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities.

Learn more about your ad choices. Visit megaphone.fm/adchoices

Quick summaries of our last 10 articles, perfect for busy people! 

61. Safety of Buprenorphine/Naloxone vs. Buprenorphine in Pregnancy 

Straub L, et al. Comparative Safety of In Utero Exposure to Buprenorphine Combined With Naloxone vs Buprenorphine Alone. JAMA. 2024 Sep 10;332(10):805-816.  

62. Naltrexone Pills vs Injections for Alcohol Use Disorder 

Magane KM, et al. Oral vs Extended-Release Injectable Naltrexone for Hospitalized Patients With Alcohol Use Disorder: A Randomized Clinical Trial. JAMA Intern Med. 2025 Jun 1;185(6):635-645. 

63. Buprenorphine Dose and Neonatal Opioid Withdrawal 

Marc B, et al. Is buprenorphine maternal dose associated with neonatal opioid withdrawal syndrome severity? Am J Addict. 2025 Jan;34(1):15-20. 

64. Screen Addiction and Suicide 

Xiao Y, et al. Addictive Screen Use Trajectories and Suicidal Behaviors, Suicidal Ideation, and Mental Health in US Youths. JAMA. 2025;334(3):219–228. 

65. Varenicline and Bupropion for Alcohol Use Disorder 

Söderpalm B, et al.  Efficacy and safety of varenicline and bupropion, in combination and alone, for alcohol use disorder: a randomized, double-blind, placebo-controlled multicentre trial. Lancet Reg Health Eur. 2025 May 13;54:101310.  

66. Smoking in Recovery 

Parks MJ, , et al. Cigarette Smoking During Recovery From Substance Use Disorders. JAMA Psychiatry. Published online August 13, 2025. 

67. Rapid-Start Injectable Buprenorphine 

Waters RC, et al. Injectable-Only Overlapping Buprenorphine Starting Protocol in a Low-Threshold Setting. JAMA Netw Open. 2025;8(8):e2527016.   

68. Behavioral Treatments as an Adjunct to Buprenorphine 

McHugh RK, et al. Behavioral Therapy as an Adjunct to Buprenorphine Treatment for Opioid Use Disorder: A Secondary Analysis of 4 Randomized Clinical Trials. JAMA Netw Open. 2025 Aug 1;8(8):e2528529. 

69. Cytisinicline for Smoking Cessation 

Rigotti NA, et al. Cytisinicline for Smoking Cessation: The ORCA Phase 3 Replication Randomized Clinical Trial. JAMA Intern Med. 2025 Jun 1;185(6):648-655. 

70. Prescription Stimulant Misuse 

Han B, Jones CM, Volkow ND, et al. Prescription Stimulant Use, Misuse, and Use Disorder Among US Adults Aged 18 to 64 Years. JAMA Psychiatry. 2025;82(6):572–581. 

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No CME for this episode, but other episodes offer category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To learn more about opportunities in addiction medicine, visit MI CARES. 

CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/  

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Original theme music: composed and performed by Benjamin Kennedy 

Audio editing: Michael Bonanno 

Executive producer: Dr. Patrick Beeman 

A podcast from Ars Longa Media 

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This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice.  

The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group. 

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Email: [email protected]  

Facebook: @AddictionMedJC 

Facebook Group: Addiction Medicine Journal Club 

Instagram: @AddictionMedJC  

Threads: @AddictionMedJC 

YouTube: addictionmedicinejournalclub  

Twitter/X: @AddictionMedJC   

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Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities.

Learn more about your ad choices. Visit megaphone.fm/adchoices

In episode 70 we discuss an

Han B, Jones CM, Volkow ND, et

We also discuss the ASAM

ASAM:Addressing

Link

STATNews:Tobacco

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This podcast offers category 1

CME:https://micaresed.org/courses/podcast-addiction-medicine-journal-club/

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Original theme music:composed

Audio editing: Michael Bonanno

Executive producer:Dr.

A podcast fromArs

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This is Addiction Medicine

The best part of any journal

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Email:

Facebook:@AddictionMedJC

Facebook Group:Addiction

Instagram:@AddictionMedJC

Threads:@AddictionMedJC

YouTube:addictionmedicinejournalclub

Twitter/X:@AddictionMedJC

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Addiction Medicine Journal

Learn more about your ad choices. Visit megaphone.fm/adchoices

In episode 69 we discuss cytisinicline for smoking cessation.

Rigotti NA, et al. Cytisinicline for Smoking Cessation: The ORCA Phase 3 Replication Randomized Clinical Trial. JAMA Intern Med. 2025 Jun 1;185(6):648-655.

We also discuss treating opioid use disorder in nursing homes and compulsive TikTok scrolling.

Carolina Public Press: NC nursing home lawsuit settlement could expand access for people with drug issues

MedicalXpress: Adults 65 years and older not immune to the opioid epidemic, study finds

Washington Post: How TikTok keeps its users scrolling for hours a day

Note: Sonya mispronounces "cytisinicline" throughout this episode. Our apologies!

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This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit MI CARES.

CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/

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This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice.

The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group.

---

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Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities.

Learn more about your ad choices. Visit megaphone.fm/adchoices

In episode 68 we discuss an article about adding behavioral treatments to buprenorphine for opioid use disorder.

McHugh RK, et al. Behavioral Therapy as an Adjunct to Buprenorphine Treatment for Opioid Use Disorder: A Secondary Analysis of 4 Randomized Clinical Trials. JAMA Netw Open. 2025 Aug 1;8(8):e2528529.

We also discuss online gambling addiction, and neuroanatomy that predisposes adolescents to addiction.

Stat News: Head of addiction medicine society warns of treatment cuts and rising threat of gambling

Miller AP, et al. Neuroanatomical Variability and Substance Use Initiation in Late Childhood and Early Adolescence.  JAMA Netw Open. 2024;7(12):e2452027.

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This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit MI CARES.

CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/

---

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This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice.

The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group.

---

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Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities.

Learn more about your ad choices. Visit megaphone.fm/adchoices

In episode 67 we discuss an article about starting buprenorphine injectables without stopping fentanyl or going into opioid withdrawal. 

Waters RC, et al. Injectable-Only Overlapping Buprenorphine Starting Protocol in a Low-Threshold Setting. JAMA Netw Open. 2025;8(8):e2527016.   

We also discuss over-the-counter magic mushrooms and banning cigarette filters.  

JAMA Network Open: Active Constituents of Psilocybin Mushroom Edibles 

The Conversation: Cigarette filters do nothing for smokers’ health and just create plastic pollution – they should be banned 

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This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit MI CARES. 

CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/  

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This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice.  

The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group. 

--- 

--- 

Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities.

Learn more about your ad choices. Visit megaphone.fm/adchoices