In episode 52 we discuss precipitated withdrawal in the era of fentanyl. 

Thakrar AP, Et al. Buprenorphine-Precipitated Withdrawal Among Hospitalized Patients Using Fentanyl. JAMA Netw Open. 2024 Sep 3;7(9):e2435895.  

We also discuss kratom, brain injury after overdose, and syringe services. 

The Kratom Sobriety Podcast 

Making Kratom Safer 

The Conversation: Brain injury after overdose is a hidden epidemic 

NIDA: Syringe services for people who inject drugs are enormously effective, but remain underused 

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This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit MI CARES. 

CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/  

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This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice.  

The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group. 

Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities. 

In episode 51 we discuss the connection between fun activities and success in recovery from substance use disorder. 

Acuff, S. F., Ellis, J. D., Rabinowitz, J. A., Hochheimer, M., Hobelmann, J. G., Huhn, A. S., & Strickland, J. C. (2024). A brief measure of non-drug reinforcement: Association with treatment outcomes during initial substance use recovery. Drug and Alcohol Dependence, 256, 111092.  

We also discuss whether people know their PCP can treat addiction, and alcohol use in Ireland. 

JAMA Network Open: Knowledge, Attitudes, and Beliefs About Opioid Use Disorder Treatment in Primary Care  

BBC: Why are people in Ireland drinking less alcohol? 

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This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit MI CARES. 

CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/ 

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This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice.  

The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group. 

Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities. 

41-50. Round-Up 

Quick summaries of our last 10 (actually 11) articles. 

41. Electronic Nicotine-Delivery Systems for Smoking Cessation

42. Quantifying a potential protective effect of buprenorphine on fatality risk during acute fentanyl exposures

43. Outcomes After Initiation of Medications for Alcohol Use Disorder at Hospital Discharge

44 Association of Cannabis Use With Cardiovascular Outcomes Among US Adults

45. Association of random and observed urine drug screening with long-term retention in opioid treatment programs

46. Smoking Cessation After Initial Treatment Failure With Varenicline or Nicotine Replacement: A Randomized Clinical Trial 

47. Extended-Release Injection vs Sublingual Buprenorphine for Opioid Use Disorder With Fentanyl Use: A Post Hoc Analysis of a Randomized Clinical Trial

48. Associations of semaglutide with incidence and recurrence of alcohol use disorder in real-world population

49. Extended observation of reduced methamphetamine use with combined naltrexone plus bupropion in the ADAPT-2 trial

50. Kratom use as more than a "self-treatment" 

Prevalence of Kratom Use Disorder Among Kratom Consumers

Long-term buprenorphine treatment for kratom use disorder: A case series

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This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice.  

The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group. 

Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities. 

In episode 50 we discuss 3 articles about kratom.

We are again joined by our friend Dr. Casey Grover from the Addiction Medicine Made Easy Podcast. 

Smith KE, Dunn KE, Rogers JM, Grundmann O, McCurdy CR, Garcia-Romeu A, Schriefer D, Swogger MT, Epstein DH. Kratom use as more than a "self-treatment". Am J Drug Alcohol Abuse. 2022 Nov 2;48(6):684-694.  

Hill K, Grundmann O, Smith KE, Stanciu CN. Prevalence of Kratom Use Disorder Among Kratom Consumers. J Addict Med. 2024 May-Jun 01;18(3):306-312. 

Broyan, V. R., Brar, J. K., Allgaier, Student, T., & Allgaier, J. T. (2022). Long-term buprenorphine treatment for kratom use disorder: A case series. Substance Abuse, 43(1), 763–766.  

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This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit MI CARES. 

CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/ 

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This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice.  

The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group. 

Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities. 

In episode 49 we discuss the 12-week follow-up data from the ADAPT-2 trial about using ER injectable naltrexone and bupropion for methamphetamine use disorder.  

Li MJ, Chau B, Belin T, Carmody T, Jha MK, Marino EN, Trivedi M, Shoptaw SJ. Extended observation of reduced methamphetamine use with combined naltrexone plus bupropion in the ADAPT-2 trial. Addiction. 2024 Jun 10. doi: 10.1111/add.16529. Epub ahead of print. PMID: 38856086. 

We also discuss fentanyl vaccines, and how easy it is to manufacture fentanyl. 

The Conversation: A new fentanyl vaccine looks promising – but treating drug addiction needs a more complex approach 

Reuters: The Fentanyl Express 

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This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit MI CARES. 

CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/ 

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This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice.  

The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group. 

Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities. 

In this episode we discuss kratom with our friend Dr. Casey Grover of the Addiction Medicine Made Easy podcast. Stay tuned for part 2 coming next, Kratom Journal Club. 

Tampa Bay Times: Deadly Dose  

Annals of Internal Medicine Kratom: An Emerging Issue for Research and Physician Education 

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This episode is not eligible for CME, but other episodes offer category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. https://micaresed.org/courses/podcast-addiction-medicine-journal-club/ 

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This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice.  

The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group. 

Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities. 

In episode 48 we discuss the association between semaglutide and alcohol use disorder. 

Wang, W., Volkow, N.D., Berger, N.A. et al. Associations of semaglutide with incidence and recurrence of alcohol use disorder in real-world population. Nat Commun 15, 4548 (2024). 

The Journal of Addiction Medicine: The Efficacy of GLP-1 Agonists in Treating Substance Use Disorder in Patients 

We also discuss THC products that look like candy, a good podcast on targeted naltrexone, and perioperative opioids. 

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This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit MI CARES. 

CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/

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This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice.  

The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group. 

Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities.

In episode 47 we discuss the effectiveness of sublingual and injectable buprenorphine for patients with OUD, with and without fentanyl. 

Nunes EV, Comer SD, Lofwall MR, Walsh SL, Peterson S, Tiberg F, Hjelmstrom P, Budilovsky-Kelley NR. Extended-Release Injection vs Sublingual Buprenorphine for Opioid Use Disorder With Fentanyl Use: A Post Hoc Analysis of a Randomized Clinical Trial. JAMA Netw Open. 2024 Jun 3;7(6):e2417377. 

We also discuss the AMA’s Support of drug decriminalization, and the rise of alcohol-related health problems. 

New York Times: Oregon Is Recriminalizing Drugs. Here’s What Portland Learned 

Med Page Today: AMA’s House of Delegates Says Yes to Drug Decriminalization 

Stat News: By the numbers: America’s alcohol-related health problems are rising fast 

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This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit MI CARES. 

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This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice. 

The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group. 

Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities. 

In episode 46 we discuss using high doses of varenicline and nicotine for smoking cessation. 

Cinciripini PM, Green CE, Shete S, Minnix JA, Robinson JD, Cui Y, Kim S, Kypriotakis G, Beneventi D, Blalock JA, Versace F, Karam-Hage M. Smoking Cessation After Initial Treatment Failure With Varenicline or Nicotine Replacement: A Randomized Clinical Trial. JAMA. 2024 May 28; 331(20):1722-1731. 

We also discuss resources for safer substance use, and the recall of dangerous Diamond Shrooms. 

Yale Program in Addiction Medicine: Resources for Safer Injection and Substance Use 

San Francisco Aids Foundation: Safer Drug Use 

CDC: Severe Illness Potentially Associated with Consuming Diamond ShruumzTM Brand Chocolate Bars, Cones, and Gummies 

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This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit MI CARES. 

CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/

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This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice. 

The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group. 

Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities. 

45. Urine Drug Screens and Treatment Retention 

In episode 45 we discuss urine drug screens and treatment retention. 

Michener PS, Knee A, Wilson D, Boama-Nyarko E, Friedmann PD. Association of random and observed urine drug screening with long-term retention in opioid treatment programs. Drug Alcohol Depend. 2024 Feb 1;255:111067.  

We also discuss storing injectable buprenorphine at room temperature and subliminal menthol in cigarettes. 

Sublocade Prescribing Information (Storage update top of page 40)  

Andre Luiz Oliveira da Silva, Lauren K. Lempert, Stanton A. Glantz. More than a “characterizing flavor”: Menthol at subliminal levels in tobacco products. Drug and Alcohol Dependence, V 261, 2024, 111346, ISSN 0376-8716. 

The Addiction Medicine Made Easy Podcast on Targeted Naltrexone

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This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit MI CARES. 

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This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice.  

The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group. 

Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities.