Addiction Medicine Journal Club

69. Cytisinicline for Smoking Cessation


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In episode 69 we discuss cytisinicline for smoking cessation.


Rigotti NA, et al. Cytisinicline for Smoking Cessation: The ORCA Phase 3 Replication Randomized Clinical Trial. JAMA Intern Med. 2025 Jun 1;185(6):648-655.


We also discuss treating opioid use disorder in nursing homes and compulsive TikTok scrolling.

Carolina Public Press: NC nursing home lawsuit settlement could expand access for people with drug issues


MedicalXpress: Adults 65 years and older not immune to the opioid epidemic, study finds


Washington Post: How TikTok keeps its users scrolling for hours a day

Note: Sonya mispronounces "cytisinicline" throughout this episode. Our apologies!

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This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit MI CARES.

CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/

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  • Original theme music: composed and performed by Benjamin Kennedy
  • Audio editing: Michael Bonanno
  • Executive producer: Dr. Patrick Beeman
  • A podcast from Ars Longa Media
  • ---

    This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice.


    The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group.

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    • Facebook: @AddictionMedJC
    • Facebook Group: Addiction Medicine Journal Club
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    • YouTube: addictionmedicinejournalclub
    • Twitter/X: @AddictionMedJC
    • ---

      Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities.

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