Yaakov's famous wrestling scene and renaming as Yisrael --one who wrestles with God and prevails-- is often understood as Yisrael wrestling with God as his opponent.  The Rabbis point out how problematic this is, since the opponent is listed as a "man," not as God.  Therefore some of the Rabbis see it this way:  the wrestling opponent looks identical to Esav, being his guardian angel (Rashi) or his projection, and wrestling "with God" (im elohim) means wrestling with God as a supportive ally.  Yaakov clearly is the Patriarch of Anxiety, and in this climax, we see a powerful message:  one does not vanquish anxiety, but rather "one who prevails" is one who does what they love (say, acting, healing, teaching, parenting, etc.) while experiencing panic and anxiety at the same time.  This is the powerful message which is both true according to science and according to Torah.