Aging-US

BUFFALO, NY—February 12, 2025 — A new #research paper was #published in Aging (Aging-US) on January 3, 2025, in Volume 17, Issue 1, titled “Characterization of DNA methylation clock algorithms applied to diverse tissue types.”

Researchers Mark Richardson, Courtney Brandt, Niyati Jain, James L. Li, Kathryn Demanelis, Farzana Jasmine, Muhammad G. Kibriya, Lin Tong, and Brandon L. Pierce from the University of Chicago and University of Pittsburgh, studied how biological aging is measured using DNA. Their study found that while commonly used “DNA methylation clocks” work well for blood samples, they may be less reliable for other tissues like the lungs, colon, and kidneys.

DNA methylation clocks are widely used in forensic science, epigenetics and longevity research to estimate a person’s biological age based on chemical changes in DNA. These epigenetic clocks help scientists predict age-related diseases and assess how lifestyle factors, such as smoking, impact aging. Most were originally developed using blood samples, and their effectiveness in other tissues remains unclear. This study tested eight different DNA methylation clocks across nine human tissue types, including the lungs, prostate, ovaries, skeletal muscle, and kidneys. The researchers analyzed data from 973 tissue samples collected through the Genotype-Tissue Expression (GTEx) project.

Their analysis revealed significant differences in biological age estimates across tissues. While blood samples provided the most reliable results, other tissues showed noticeable variations. For example, testis and ovary tissues appeared younger than expected, while lung and colon tissues appeared older.

“These differences across tissue types were most apparent for clocks trained using DNAm from blood only (e.g., Hannum), but also present for clocks trained on multiple tissue types (e.g., Horvath, a clock designed for pan-tissue age prediction.”

These findings suggest that aging may not occur at the same rate in every organ, and that standard DNA methylation clocks may not always give accurate biological age estimates outside of blood samples. The authors suggest that new, organ-specific epigenetic clocks may be needed to improve biological age prediction. Creating tissue-specific aging clocks could also improve medical diagnostics, age-related disease prevention, and health monitoring.

The researchers emphasize that larger studies with more tissue-specific DNA methylation data are needed to refine these aging clocks. By improving these tools, scientists can better understand how aging affects different organs and develop more reliable methods for measuring biological age. These advancements could lead to better predictions of age-related diseases and new strategies for healthy aging.

DOI - https://doi.org/10.18632/aging.206182

Corresponding author - Brandon L. Pierce - [email protected]

Video short - https://www.youtube.com/watch?v=Jz-daRsZO2o

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About Aging-US

The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population.

The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.)

Please visit our website at https://www.Aging-US.com​​ and connect with us:

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BUFFALO, NY—February 11, 2025 — A new #research paper was #published in Aging (Aging-US) on January 15, 2025, in Volume 17, Issue 1, titled “Association between physical activity practice and sleep quality of older people in social isolation during the COVID-19 pandemic and Health Guidelines and future studies for the post-COVID period: a systematic review.”

Researchers Alexandro Andrade, Ana Cecília Rosatelli de Freitas Bastos, Anderson D’Oliveira, and Guilherme Torres Vilarino from the Santa Catarina State University (UDESC) in Brazil, conducted a systematic review to examine the relationship between physical activity (PA) and sleep quality in older adults who experienced social isolation during the COVID-19 pandemic. Their findings reveal that a decline in PA levels during social isolation negatively impacted sleep health, emphasizing the need for regular movement in aging populations.

The study reviewed nine studies involving over 11,500 older adults of both sexes from China, Japan, Brazil, Scotland, Canada, Italy, and Spain. The results showed that reduced PA during the pandemic was linked to poorer sleep quality in four studies, while one study found that those who remained active had better sleep patterns. The four other studies showed no significant association.

Getting enough quality sleep is essential for healthy aging, as sleep disorders have been linked to cognitive decline, depression, and reduced mental well-being. The COVID-19 pandemic worsened sleep health due to increased stress, isolation, and anxiety. Researchers suggest that staying active through walking, stretching, and structured exercise routines may help improve sleep quality and overall mental health.

The researchers point out the importance of PA as an accessible way to enhance sleep quality in older adults, particularly during times of crisis. Encouraging regular exercise and movement may help prevent sleep disorders and improve overall well-being in aging populations.

“PA can be considered a safe and effective practice to improve sleep quality in older adults due to its well-documented benefits in the literature.”

As the world moves past the pandemic, the researchers call for public health policies that promote PA for seniors. Health professionals and caregivers should advocate for regular movement as a preventive measure against insomnia, poor sleep, and mental health issues while emphasizing the long-term consequences of physical inactivity. The study also highlights the need for further research on the most effective types and intensities of PA for improving sleep quality in older adults.

“The practice of exercise and PA, individually and in groups, is recommended for this post-COVID scenario, as a measure to reduce social isolation and its negative effects and improve the quality of sleep in older adults.”

Future studies should explore how different exercise routines impact sleep health, especially for older adults recovering from COVID-19 or facing ongoing sleep challenges.

DOI - https://doi.org/10.18632/aging.206180

Corresponding author - Alexandro Andrade - [email protected]

Video short - https://www.youtube.com/watch?v=uV4WXq7I_J0

About Aging-US

The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population.

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Emerging research suggests that a specific type of body fat may play an important role in healthy aging and physical performance. Researchers from Rutgers New Jersey Medical School explore this topic in a recent research perspective published in Aging (Aging-US). Their work discusses new findings and emerging ideas about the role of brown adipose tissue (BAT), commonly known as brown fat.

Understanding Brown Fat

The human body contains different types of fat. The most common is white adipose tissue (WAT), which primarily stores excess calories. When present in large amounts, WAT contributes to health problems like obesity, type 2 diabetes, and cardiovascular disease as a result of its role in metabolic imbalance.

In contrast, BAT serves a more dynamic role. Instead of storing energy, BAT burns calories to generate heat through a process called thermogenesis, powered by its high concentration of mitochondria—the energy-producing structures in cells. While BAT is abundant in newborns to help regulate body temperature, it persists in smaller amounts in adults, particularly around the neck, shoulders, and spine.

According to the research perspective, titled “Brown Adipose Tissue Enhances Exercise Performance and Healthful Longevity” brown fat’s role extends beyond thermoregulation. The authors suggest that BAT can significantly improve metabolic health, enhance physical performance, and promote healthful longevity.

Full blog - https://aging-us.org/2025/02/the-hidden-power-of-brown-fat-a-new-ally-in-healthy-aging/

Paper DOI - https://doi.org/10.18632/aging.206179

Corresponding author - Stephen F. Vatner - [email protected]

Video short - https://www.youtube.com/watch?v=n1DvuR7owJQ

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Keywords - aging, brown adipose tissue, white adipose tissue, healthful longevity, exercise, regulator of G protein signaling 14

About Aging-US

The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population.

The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.)

Please visit our website at https://www.Aging-US.com​​ and connect with us:

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BUFFALO, NY—February 5, 2025 — A new #research paper was #published in Aging (Aging-US) on November 27, 2024, in Volume 17, Issue 1, titled “Neurocognitive disparities: investigating ethnicity and mental health in rural aging adults.”

Researchers Carol Fadalla, Jonathan Singer,, Peter Rerick, Lauren Elliott, Elisabeth McLean, Sydnie Schneider, Lauren Chrzanowski, Veronica Molinar-Lopez, and Volker Neugebauer from Texas Tech University and the University of Central Oklahoma studied how depression and anxiety affect memory and thinking skills in Hispanic and non-Hispanic White older adults living in rural areas. They found clear differences in brain health, with Hispanic older adults scoring lower on tests of memory, attention, and problem-solving, even when their mental health was similar to non-Hispanic White participants. This suggests that Hispanic older adults may face unique challenges that affect their brain health, highlighting the need for support programs tailored to their specific needs.

As the U.S. population grows older, more people are being diagnosed with conditions like Alzheimer’s disease, dementia, and other memory-related illnesses. This issue is even more serious in rural communities where healthcare services are limited. Hispanic older adults, who make up a large part of the rural population, are at an even higher risk of developing these brain health issues.

In this study, researchers analyzed data from over 1,400 adults aged 40 and older from rural communities in Texas. Participants completed tests measuring memory, problem-solving, and attention, along with surveys about depression and anxiety. While depression and anxiety were linked to poorer thinking skills, they did not fully explain the brain health differences between Hispanic and non-Hispanic White participants. In fact, ethnic background alone explained about 20% of the differences in brain health, showing its strong impact on cognitive performance.

The study also found that other factors, such as lifelong stress, limited access to healthcare, language barriers, discrimination, social isolation, and fewer educational opportunities, may contribute to these brain health differences. These challenges seem to affect Hispanic older adults more, increasing their risk of memory and thinking problems as they age.

The researchers emphasize the need to look beyond mental health to fully understand brain health differences in older adults. They recommend that healthcare providers consider social, economic, and cultural factors when developing programs to support cognitive health. Adding memory and thinking tests to regular checkups could help detect early signs of cognitive decline.

“Culturally tailored interventions targeting risk factors for neurocognitive impairment in Hispanic rural aging adults are imperative to mitigate neurocognitive disparities.”

By understanding the unique challenges faced by Hispanic older adults, programs that better support brain health can be created. Involving local community leaders in designing these programs can make them more effective, helping all older adults maintain their memory and thinking skills as they age.

Read the full paper: DOI: https://doi.org/10.18632/aging.206166

Corresponding author: Jonathan Singer - [email protected]

About Aging-US

The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population.

The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.)

Please visit our website at https://www.Aging-US.com​​.

BUFFALO, NY—February 4, 2025 — A new #research paper was #published by Aging (Aging-US) on December 3, 2024, in Volume 17, Issue 1, titled “Topical ABT-263 treatment reduces aged skin senescence and improves subsequent wound healing.”

Researchers Maria Shvedova, Rex Jeya Rajkumar Samdavid Thanapaul, Joy Ha, Jannat Dhillon, Grace H. Shin, Jack Crouch, Adam C. Gower, Sami Gritli, and Daniel S. Roh from Boston University Aram V. Chobanian and Edward Avedisian School of Medicine have discovered that a drug called ABT-263 can significantly improve wound healing in aging skin. When applied directly to the skin of older mice, ABT-263 helps clear out old, damaged cells, known as senescent cells, and speeds up the skin’s ability to heal after injury. This finding could lead to new treatments for slow-healing wounds in older adults, especially for post-surgical recovery and chronic wound care.

As people age, their bodies accumulate senescent cells—damaged cells that no longer function properly but refuse to die. The buildup of these cells in tissues like the skin slows down the body’s ability to heal after injuries. This study investigated whether ABT-263, a senolytic drug designed to target and remove senescent cells when applied topically, could enhance the skin’s natural healing process.

Researchers applied ABT-263 to the skin of aged mice for five days. The treated skin showed fewer signs of cellular aging, and when small wounds were created, they healed much faster compared to untreated mice. By day 24, 80% of the mice treated with ABT-263 had fully healed wounds, compared to just 56% of untreated mice.

Interestingly, ABT-263 triggered a brief spike of inflammation in the skin, which surprisingly helped the healing process. The inflammation seemed to “wake up” the skin’s repair systems, making them respond more quickly to wounds. Additionally, ABT-263 increased the activity of genes related to wound repair, such as those involved in collagen production and the growth of new blood vessels, both essential for skin strength and regeneration.

The study also found that ABT-263 selectively reduced senescent cells in aged mice without affecting young mice, suggesting the drug is particularly effective in older tissues where these damaged cells accumulate. Moreover, because ABT-263 was applied directly to the skin, it avoided the common side effects associated with oral senolytic drugs.

“Our study underscores the potential of topical senolytic treatments to enhance wound healing in aging skin, presenting a potentially promising strategy for preoperative care.”

While the results are promising, more research is needed to confirm whether this treatment is safe and effective for humans. However, this study represents an exciting step forward in regenerative medicine, opening new opportunities to improve wound healing in aging skin.

DOI - https://doi.org/10.18632/aging.206165

Corresponding author - Daniel S. Roh - [email protected]

Video short - https://www.youtube.com/watch?v=AKS7sZyEChg

About Aging-US

The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population.

The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.)

Please visit our website at https://www.Aging-US.com​​ and connect with us:

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BUFFALO, NY- January 29, 2025 – A new #editorial was #published in Volume 16, Issue 22 of Aging (Aging-US) on December 11, 2024, titled “ISarcoPRM algorithm for global operationalization of sarcopenia diagnosis.”

In this editorial, Pelin Analay, Murat Kara and Levent Özçakar from Hacettepe University Medical School discuss the importance of establishing a standardized global approach to diagnosing sarcopenia, an age-related condition that leads to muscle loss and reduced strength. The authors highlight the ISarcoPRM algorithm, which suggests measuring quadriceps muscle mass instead of the commonly used appendicular lean mass (ALM) measurement. They believe this improved method could help clinicians identify sarcopenia earlier and provide better treatment options.

Sarcopenia is a major health problem for older adults, making daily activities such as walking, climbing stairs, and standing up more difficult. As muscle strength declines, individuals with sarcopenia are at greater risk of falls and serious injuries, such as fractures. Early detection of sarcopenia is crucial to help older adults maintain their mobility and independence.

The editorial points out that current diagnostic tools, such as dual-energy X-ray absorptiometry (DXA), may not effectively measure age-related muscle loss. Sarcopenia primarily affects fast-twitch muscle fibers, which are essential for strength and quick movements. However, DXA scans measure overall muscle mass and fail to assess these specific fibers, potentially leading to inaccurate or delayed diagnoses.

The authors propose that measuring the quadriceps muscle mass—the large muscle in the thigh—is a more accurate way to diagnose sarcopenia. This muscle plays a critical role in mobility and strength, and its size and function are strongly linked to a person's overall physical performance. The editorial recommends using ultrasound (US) imaging as a practical and cost-effective solution for diagnosing sarcopenia in clinical settings. Compared to other imaging techniques, US is affordable, widely available, and well-suited for elderly patients, including those with mobility limitations or medical implants. Ultrasound is also non-invasive, making it an ideal choice for routine sarcopenia screening in hospitals, clinics, and long-term care facilities.

If widely adopted, this new way of diagnosing sarcopenia could help clinicians detect it more accurately and at an earlier stage. Finding sarcopenia early allows people to start helpful treatments, like exercise, better nutrition, and healthy lifestyle changes. These steps can slow down muscle loss and help older adults stay strong and active. Finally, the authors encourage a global consensus on how to diagnose sarcopenia and suggest the ISarcoPRM method as a great option.

“In conclusion, quadriceps muscle mass measurements, preferably by US and as recommended by the ISarcoPRM algorithm, holds great promise in the diagnosis of sarcopenia.”

DOI - https://doi.org/10.18632/aging.206174

Corresponding author - Pelin Analay - [email protected]

Video short - https://www.youtube.com/watch?v=gDcQ9w6mHyE

About Aging-US

The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population.

Please visit our website at https://www.Aging-US.com​​ and connect with us:

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BUFFALO, NY- January 28, 2025 – A new #research paper was #published in Volume 16, Issue 22 of Aging (Aging-US) on December 20, 2024, titled, “Impaired renal transporter gene expression and uremic toxin excretion as aging hallmarks in cats with naturally occurring chronic kidney disease.”

This study, led by researchers Qinghong Li, James A. Holzwarth, Bethany Smith, Sonia Karaz, Mathieu Membrez, Vincenzo Sorrentino, Stacie Summers, Julie Spears, and Eugenia Migliavacca from Nestlé Purina Research and Oregon State University, explores how aging affects kidney function in cats with chronic kidney disease (CKD). The researchers found that older cats have lower levels of important kidney transporter genes, which usually help remove harmful waste products from the blood. These findings could help veterinarians better understand CKD in aging cats and offer insights that may be relevant to human kidney health.

"Chronic kidney disease (CKD) is a naturally occurring kidney disease common in both geriatric cats and older people. Despite differing etiology, both species share many pathophysiological similarities, including chronic tubulointerstitial inflammation and fibrosis."

Older cats with CKD struggle to filter toxins from their bloodstream effectively. In this study, the researchers analyzed kidney samples from two cat cohorts aged 6 to 21 years. The cohort number one included 41 colony cats: 28 control and 13 CKD cats. The cohort number two had 30 privately owned cats with 10 control and 20 CKD cats. They discovered that certain transporter genes, such as OAT1, OAT4, OATP4C1 and ABCC2, were significantly decreased in cats with CKD compared to healthy cats. The research team also found increased levels of harmful toxins in the blood of cats with CKD. Even healthy older cats had higher toxin levels compared to younger cats, showing that aging itself might contribute to declining kidney function.

Monitoring kidney transporters levels and toxin buildup may help detect the disease early and improve treatment options. The researchers highlight the importance of regular veterinary check-ups to catch kidney problems early and keep cats healthier for longer.

Because cats and humans share similar kidney health challenges, studying feline CKD can provide valuable insights into human kidney disease and aging. Continued research is essential to develop treatments that may improve kidney function in aging cats and potentially benefit humans as well.

DOI - https://doi.org/10.18632/aging.206176

Corresponding author - Qinghong Li - [email protected]

Video short - https://www.youtube.com/watch?v=WuEP9PXtx2A

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Keywords - aging, trimethylamine N-oxide, indoxyl sulfate, OAT1, OATP4C1, ABCC2

About Aging-US

The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population.

The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.)

Please visit our website at https://www.Aging-US.com​​ and connect with us:

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“We illustrate our strategy in brain and liver tissue, demonstrating how cell-type specific epigenetic clocks from these tissues can improve tissue-specific estimation of chronological and biological age.”

Aging affects everyone differently. There are two types of aging: chronological aging, which refers to the number of years a person has lived, and biological aging, which reflects how well the body is functioning based on cellular changes. A recent study published as the cover for Volume 16, Issue 22 of Aging reports a new discovery that could revolutionize the way we understand aging and its impact on health.

Understanding Biological Age

Biological age reflects how well the body is aging and can vary based on lifestyle, genetics, and environmental factors. Traditionally, scientists estimate it using epigenetic clocks, which measure DNA methylation, chemical changes that occur over time. Until recently, these clocks could only provide general estimates by analyzing entire tissues, meaning they could not distinguish how different cell types aged within those tissues. A recent study titled “Cell-type Specific Epigenetic Clocks to Quantify Biological Age at Cell-Type Resolution” aims to change that.

Full blog - https://aging-us.org/2025/01/how-scientists-are-measuring-aging-at-the-cellular-level/

Paper DOI - https://doi.org/10.18632/aging.206184

Corresponding author - Andrew E. Teschendorff - [email protected]

Video short - https://www.youtube.com/watch?v=FjJa5U2-AqQ

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Keywords - aging, DNA methylation, epigenetic clocks, cell-type deconvolution, biological aging, Alzheimer’s disease, obesity

About Aging-US

The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population.

The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.)

Please visit our website at https://www.Aging-US.com​​ and connect with us:

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BUFFALO, NY- January 22, 2025 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) on December 12, 2024, Volume 16, Issue 22, titled “Arginase-II gene deficiency reduces skeletal muscle aging in mice.”

Researchers Matteo Caretti, Duilio Michele Potenza, Guillaume Ajalbert, Urs Albrecht, Xiu-Fen Ming, Andrea Brenna, and Zhihong Yang from the University of Fribourg found that removing a specific gene, called arginase-II (Arg-II), can slow down muscle aging in mice. Their research showed that older mice lacking this gene stayed more active and had healthier skeletal muscles compared to normal aging mice. This discovery could lead to new treatments to help people maintain muscle strength and mobility as they become older.

As people age, their muscles naturally get weaker, leading to reduced physical activity and overall quality of life. This condition, known as sarcopenia, occurs because of muscle fiber loss, inflammation, and scar tissue buildup. The study found that the Arg-II gene contributes to this process.

The research team compared normal mice with mice lacking the Arg-II gene and discovered that in general, the mice without the gene had improved muscle health, reduced inflammation, and fewer signs of age-related muscle decline. It was also found that older male mice deficient in the Arg-II gene were more active, particularly during their peak nighttime activity. These mice had stronger muscles and performed better in physical tests. Interestingly, the benefits of Arg-II gene removal were more pronounced in male mice compared to females, suggesting that hormonal or genetic differences might play a role in age-related muscle loss.

“The improved phenotype of arg-ii-/- mice in aging is associated with reduced sarcopenia, cellular senescence, inflammation, and fibrosis, whereas age-associated decline of microvascular endothelial cell density, satellite cell numbers, and muscle fiber types in skeletal muscle is prevented in arg-ii-/- mice.”

ARG-II protein was not found in muscle fibers but instead in surrounding cells such as fibroblasts and blood vessel cells, which makes scientists believe this gene influences muscle aging indirectly. Independently of that, the findings suggest that targeting the Arg-II gene could help slow down age-related muscle deterioration and improve muscle function in older adults.

"[...] we demonstrate an increased arg-ii gene expression level in aging skeletal muscle and found Arg-II protein expression in endothelial cells and fibroblasts, but not in skeletal muscle fibers, macrophages, and satellite cells."​

While these results are promising, further research is needed to determine whether blocking the Arg-II gene in humans could provide similar benefits. Furthermore, understanding why male and female mice responded differently to the gene removal will be essential before personalized treatments for age-related muscle loss. If future studies confirm these findings in humans, targeting Arg-II could become a valuable strategy to help adults maintain muscle strength, mobility, and overall quality of life as they age.

DOI - https://doi.org/10.18632/aging.206173

Corresponding authors - Andrea Brenna - [email protected], and Zhihong Yang - [email protected]

Video short - https://www.youtube.com/watch?v=uDxSCO2Y7-w

About Aging-US

The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population.

The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.)

Please visit our website at https://www.Aging-US.com​​.

BUFFALO, NY- January 21, 2025 — Aging (Aging-US) (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) partners with the inaugural Global Conference on Gerophysics, taking place from March 5–6, 2025, in Singapore. This groundbreaking event marks the launch of Gerophysics, an innovative field that applies theoretical physics concepts to the biology of aging, aiming to extend healthy human lifespans.

The Intersection of Physics and Aging

Theoretical physics has long revolutionized diverse industries—reshaping finance, powering artificial intelligence breakthroughs, and transforming our understanding of the cosmos. Now, leading experts are applying these powerful methodologies to tackle one of humanity's most profound challenges: aging.

Hosted by the National University of Singapore (NUS) Yong Loo Lin School of Medicine, the Global Conference on Gerophysics - “where physics meets aging biology” - aims to bridge statistical mechanics, complex systems theory, and dynamical modeling with the biological mechanisms of aging. This unique interdisciplinary approach has the potential to reshape our understanding of the aging process and revolutionize efforts to promote healthy longevity.

A Collaborative Platform for Innovation

The conference will bring together leading scientists, researchers, and thought leaders from across the globe to:

-Develop a shared scientific language and toolkit for aging research.

-Explore novel frameworks for studying biological aging through the lens of physics.

-Foster collaborations that could lead to breakthroughs in extending human healthspan.

As a media partner, Aging (Aging-US) is committed to amplifying the impact of this pioneering initiative, ensuring that groundbreaking insights and discussions reach the global scientific community.

Stay updated on the conference via LinkedIn: Centre for Healthy Longevity, X (formerly Twitter): @HealthyLongeviT or visit the official event page.

Key Words: aging, gerophysics, longevity research, conference, physics, biology, meeting, collaboration, lifespan, healthspan

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