Aging-US

Blog summary of a trending research paper published by Aging (Aging-US) in Volume 14, Issue 6, entitled, “Ovarian reserve parameters and IVF outcomes in 510 women with poor ovarian response (POR) treated with intraovarian injection of autologous platelet rich plasma (PRP).”

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In a day and age when women and men are beginning families later in the life cycle, women of advanced age (or with some health conditions) often have trouble becoming pregnant. Today, in vitro fertilization (IVF) is a widely-used form of assisted reproductive technology. This manual process of fertilization is achieved first by combining an egg and a sperm outside of the uterus and then helping the fertilized egg become implanted in the uterus.

The world’s first IVF baby was born in Lancashire, England, in 1978. Since then, this technique has solved reproductive issues for millions of women and men around the world. While this procedure has helped build many families, there is a subset of reproductively challenged women who exhibit resistance to IVF. Researchers have observed accelerated ovarian aging in women who demonstrate a poor ovarian response (POR) to IVF.

“These women are labeled ‘poor ovarian response’ (POR) or ‘poor responders’ due to a combination of low parameters of ovarian reserve and previous low oocyte yield after ovarian stimulation.”

In previous small-scale cohort and in vitro studies, exposure to platelet-rich plasma (PRP) has demonstrated improvements in ovarian tissue repair, regeneration and follicular development. In a new study, published in Aging (Aging-US) on March 22, 2022, researchers— from Acibadem Maslak Hospital, Acibadem University, IVI RMA New Jersey, Thomas Jefferson University, and Yale School of Medicine—sought to validate these small-scale results by assessing the effects of intra-ovarian injection of autologous PRP in a cohort of 510 women with POR. Their trending research paper can be found in Volume 14, Issue 6, entitled, “Ovarian reserve parameters and IVF outcomes in 510 women with poor ovarian response (POR) treated with intraovarian injection of autologous platelet rich plasma (PRP).”

Full blog - https://aging-us.org/2022/04/trending-with-impact-plasma-injection-improves-poor-response-to-ivf/

DOI - https://doi.org/10.18632/aging.203972

Corresponding author - Emre Seli - [email protected]

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Keywords - poor ovarian response, platelet rich plasma, in vitro fertilization

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at http://www.Aging-US.com​​ and connect with us:

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Aging-US is published by Impact Journals, LLC: http://www.ImpactJournals.com​​

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Listen to a blog summary of a research paper chosen as the cover for Volume 14, Issue 6 of Aging (Aging-US), entitled, "Hallmarks of aging-based dual-purpose disease and age-associated targets predicted using PandaOmics AI-powered discovery engine."

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What if drugs designed to treat conditions such as diabetes, osteoporosis and rheumatoid arthritis could at the same time provide patients with anti-aging benefits? On March 29, 2022, researchers—from Insilico Medicine, University of Chicago, George Mason University, University of Liverpool, and Buck Institute for Research on Aging—released a new study on the cover of Aging (Aging-US) Volume 14, Issue 6, about Insilico’s next-generation artificial intelligence (AI)-powered discovery software, called the PandaOmics platform. Their trending research paper is entitled, “Hallmarks of aging-based dual-purpose disease and age-associated targets predicted using PandaOmics AI-powered discovery engine.”

Full blog - https://aging-us.org/2022/03/pandaomics-identifies-duel-targets-of-aging-and-age-related-diseases/

DOI - https://doi.org/10.18632/aging.203960

Corresponding author - Alex Zhavoronkov - [email protected]

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Keywords - aging, artificial intelligence, deep learning, drug discovery, multi-omics, target identification

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at http://www.Aging-US.com​​ or connect with us:

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Listen to a blog summary of the announcement for a special collection of Steve Horvath research papers published by Aging (Aging-US).

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Epigenetics is the study of gene expression and the changes that occur which do not involve alterations in the DNA sequence. These changes can occur as a result of environmental influences, including exposure to chemicals, diet and stress. Epigenetic modifications can be passed down through generations and play an important role in disease development. An exciting area of epigenetics research is its role in the aging process. Studies have shown that epigenetic modifications can affect aging and the onset of age-related diseases. Recently, researchers also discovered that epigenetic modifications may be used to measure biological age and aging rate.

Steve Horvath, Ph.D., ScD is a world-renowned researcher, geneticist, biostatistician, and Professor of Human Genetics and Biostatistics at the University of California, Los Angeles. His research areas of study include aging, cancer, cardiovascular disease, HIV, Huntington’s disease, and neurodegenerative diseases. Today, he is well-known for his contributions in epigenetics research. In 2013, Dr. Horvath developed the first multi-tissue DNA methylation-based epigenetic biomarker of aging, known as the Horvath aging clock. Dr. Horvath earned numerous awards for his groundbreaking research, including the Allen Distinguished Investigator award, the Open Philanthropy Project award and the Schober Award. In 2018, 2019, 2020, and 2021, the Clarivate Web of Science Group named him as one of the world’s most influential scientific researchers.

Full blog - https://aging-us.net/2022/03/special-collection-of-steve-horvath-publications-in-aging/

Steve Horvath Special Collection - https://www.aging-us.com/special-collections-archive/steve-horvath

Contact information - Steve Horvath - [email protected]

Keywords - aging, aging research, epigenetics, epigenetic clock, longevity, healthspan, lifespan, lifestyle, research, research papers

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at http://www.Aging-US.com​​ and connect with us:

SoundCloud - https://soundcloud.com/Aging-Us

Facebook - https://www.facebook.com/AgingUS/

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Aging-US is published by Impact Journals, LLC: http://www.ImpactJournals.com​​

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Dr. Brian Chen, adjunct faculty at the Herbert Wertheim School of Public Health and Human Longevity Science at UC San Diego and the Chief Science Officer of FOXO Technologies, describes his experience publishing numerous papers with Aging (Aging-US).

Aging (Aging-US) papers co-authored by Dr. Chen:

Predicting physiological aging rates from a range of quantitative traits using machine learning:

https://doi.org/10.18632/aging.203660

An epigenetic biomarker of aging for lifespan and healthspan:

https://doi.org/10.18632/aging.101414

Leukocyte telomere length, T cell composition and DNA methylation age:

https://doi.org/10.18632/aging.101293

Epigenetic clock analysis of diet, exercise, education, and lifestyle factors:

https://doi.org/10.18632/aging.101168

DNA methylation-based measures of biological age: meta-analysis predicting time to death:

https://doi.org/10.18632/aging.101020

Contact information - Brian Chen - [email protected]

Keywords - aging, aging clock, mortality, machine learning, epigenetic clock, DNA methylation, biomarker, healthspan, diet, lifestyle, lifespan, epigenetics, all-cause mortality

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at http://www.Aging-US.com​​ or connect with us:

SoundCloud - https://soundcloud.com/Aging-Us

Facebook - https://www.facebook.com/AgingUS/

Twitter - https://twitter.com/AgingJrnl

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YouTube - https://www.youtube.com/agingus​

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Aging-US is published by Impact Journals, LLC: http://www.ImpactJournals.com​​

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Listen to a blog summary of a trending editorial published in Volume 14, Issue 5 of Aging (Aging-US), entitled, “Sex matters in Alzheimer’s disease?“

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As the worldwide elderly population continues to expand, the symptoms of dementia, including Alzheimer’s disease (AD), are simultaneously increasing around the globe. Researchers are driven to investigate new ways to detect and treat AD in earlier stages—before symptoms become more difficult or impossible to overturn. An important piece of data to consider is that dementia is more prevalent among women than among men; dementia affects 8.1 % of women and 5.4% of men. Many AD studies have not used gender/sex as a variable to cross-examine their research findings. This information may be a key factor that leads to developing more efficacious strategies for AD detection and treatment in all patients, and especially in women.

“In the long run, the underrepresentation of female biology in biomedical research will hamper the development of effective drugs with negative consequences on women’s health.”

In a recent editorial paper published on March 12, 2022, by Aging (Aging-US) in Volume 14, Issue 5, researchers from the National University of Singapore discussed the importance of understanding sex differences in Alzheimer’s disease. Their trending editorial paper, entitled, “Sex matters in Alzheimer’s disease?“, was based on results from their previous study published in 2021.

Full blog - https://aging-us.org/2022/03/trending-with-impact-how-biological-sex-impacts-alzheimers-disease/

DOI - https://doi.org/10.18632/aging.203950

Corresponding author - Sreedharan Sajikumar - [email protected]

Keywords - Alzheimer's disease, LTP, behavioural tagging, sexual dimorphism, transcriptome profiling

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at http://www.Aging-US.com​​ and connect with us:

SoundCloud - https://soundcloud.com/Aging-Us

Facebook - https://www.facebook.com/AgingUS/

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Aging-US is published by Impact Journals, LLC: http://www.ImpactJournals.com​​

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Listen to a blog summary of a trending research paper selected as the cover for Volume 14, Issue 5 of Aging (Aging-US), entitled, "Depletion of transmembrane mucin 4 (Muc4) alters intestinal homeostasis in a genetically engineered mouse model of colorectal cancer."

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With age, humans undergo bodily changes which include a decline in organ and tissue function. The average age men and women are diagnosed with colorectal cancer (CRC) is 68 and 72 years old, respectively. Healthy intestinal epithelial cells are usually lined with a sufficient layer of mucus; important components in this mucus layer, called mucins, help to maintain physiological homeostasis. While transmembrane mucin 4 (Muc4) has been found to be overexpressed in pancreatic, ovarian and breast cancers, Muc4 expression is decreased in patients with CRC. The functional role and implications of Muc4 in CRC’s intestinal pathology have not yet been adequately investigated.

Researchers—from the University of Nebraska Medical Center, Baylor College of Medicine, University of California San Diego, and VA San Diego Healthcare System—sought to better understand the role of Muc4 in CRC by developing genetically engineered mouse (GEM) models. Their priority research paper was published as the cover of Aging-US Volume 14, Issue 5, and entitled, “Depletion of transmembrane mucin 4 (Muc4) alters intestinal homeostasis in a genetically engineered mouse model of colorectal cancer.“

“Therefore, to understand the functional significance of MUC4 in intestinal homeostasis and CRC progression, we developed a GEM model by crossing mice carrying a conditional mutation of Apc [adenomatous polyposis coli] gene with colon-specific caudal type homeobox transcription factor 2 (Cdx2)-Cre fused with estrogen receptor.”

Full blog post - https://aging-us.org/2022/03/trending-with-impact-muc4-role-in-intestinal-balance-and-cancer/

DOI - https://doi.org/10.18632/aging.203935

Corresponding author - Surinder K. Batra - [email protected]

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Keywords - aging, mucin, MUC4, intestinal homeostasis, colorectal cancer

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at http://www.Aging-US.com​​ or connect with us:

SoundCloud - https://soundcloud.com/Aging-Us

Facebook - https://www.facebook.com/AgingUS/

Twitter - https://twitter.com/AgingJrnl

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YouTube - https://www.youtube.com/agingus​

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Aging-US is published by Impact Journals, LLC: http://www.ImpactJournals.com​​

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Dennis Mangan from MTOR LLC in Bakersfield, California describes his experience publishing his theory article, “Iron: an underrated factor in aging,” in Volume 13, Issue 19 of Aging (Aging-US).

DOI - https://doi.org/10.18632/aging.203612

Corresponding author - Dennis Mangan - [email protected]

Abstract

Iron is an essential element for virtually all living organisms, but its reactivity also makes it potentially harmful. Iron accumulates with aging, and is associated with many age-related diseases; it also shortens the lifespans of several model organisms. Blocking iron absorption through drugs or natural products extends lifespan. Many life-extending interventions, such as rapamycin, calorie restriction, and old plasma dilution can be explained by the effects they have on iron absorption, excretion, and metabolism. Control of body iron stores so that they remain in a low normal range may be an important, lifespan- and healthspan-extending intervention.

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Press release - https://www.aging-us.com/news_room/iron-an-underrated-factor-in-aging

Blog post - https://www.impactjournals.com/journals/blog/aging/trending-with-impact-is-iron-a-driver-of-aging/

Mangan interview with Dr. Mikhail Blagosklonny - https://www.youtube.com/watch?v=e-if3zjYSfY

Keywords - iron, aging, oxidative stress, calorie restriction, plasma dilution

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at http://www.Aging-US.com​​ or connect with us:

SoundCloud - https://soundcloud.com/Aging-Us

Facebook - https://www.facebook.com/AgingUS/

Twitter - https://twitter.com/AgingJrnl

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YouTube - https://www.youtube.com/agingus​

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Aging-US is published by Impact Journals, LLC: http://www.ImpactJournals.com​​

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Listen to a blog summary of a trending research paper published by Aging (Aging-US) on February 16, 2022, entitled, “Elevated levels of serum CDCP1 in individuals recovering from severe COVID-19 disease.”

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Among people who have been fortunate to recover from COVID-19, at least 40% had or have long-term lingering effects from this disease. Sometimes appearing months after recovering, these “long covid” effects can include (not limited to) fatigue, trouble sleeping, difficulty concentrating, joint or muscle pain, and respiratory issues, such as shortness of breath and chest pain. Researchers are still unsure as to whether or not lasting COVID-19 effects in the lungs are associated with the severity of disease at the time of infection.

“Thus, prospective studies related to outcomes following recovery from COVID-19 might improve our understanding of this disease, its sequelae, and possible interventions to improve this situation.”

Researchers—from Hospital Universitario San Pedro, Centro de Investigación Biomédica de La Rioja, Universidad de Córdoba, Hospital Universitario Reina Sofía, Hospital Costal de Sol, HCU Lozano Blesa, Hospital Universitario Marqués de Valdecilla, Unidad de Enfermedades Infecciosas, Hospital Universitario de Burgos, Vitro Laboratory, Instituto de Investigación-IdiPaz, and Universidad Rey Juan Carlos—conducted a new study aimed at identifying biomarkers of severe disease in patients after hospitalization for COVID-19. Their research paper was published by Aging (Aging-US) on February 16, 2022, and entitled, “Elevated levels of serum CDCP1 in individuals recovering from severe COVID-19 disease.”

Full blog - https://aging-us.org/2022/03/trending-with-impact-do-biomarkers-of-long-covid-exist/

DOI - https://doi.org/10.18632/aging.203898

Corresponding Author - Jose-Ramon Blanco - [email protected]; https://orcid.org/0000-0002-4268-0150

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Keywords - biomarkers, CDCP1, recovery, COVID-19

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at http://www.Aging-US.com​​ and connect with us:

SoundCloud - https://soundcloud.com/Aging-Us

Facebook - https://www.facebook.com/AgingUS/

Twitter - https://twitter.com/AgingJrnl

Instagram - https://www.instagram.com/agingjrnl/

YouTube - https://www.youtube.com/agingus​

LinkedIn - https://www.linkedin.com/company/aging/

Pinterest - https://www.pinterest.com/AgingUS/

Aging-US is published by Impact Journals, LLC: http://www.ImpactJournals.com​​

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Dr. Andrei Gudkov of the Roswell Park Cancer Institute in Buffalo, NY discusses the research paper he co-authored that was published by Aging (Aging-US) in Volume 9, Issue 8, entitled, "p16(Ink4a) and senescence-associated β-galactosidase can be induced in macrophages as part of a reversible response to physiological stimuli."

DOI - https://doi.org/10.18632/aging.101268

Correspondence to - Olga Chernova - [email protected] and Andrei Gudkov - [email protected]

Abstract:

Constitutive p16Ink4a expression, along with senescence-associated β-galactosidase (SAβG), are commonly accepted biomarkers of senescent cells (SCs). Recent reports attributed improvement of the healthspan of aged mice following p16Ink4a-positive cell killing to the eradication of accumulated SCs. However, detection of p16Ink4a/SAβG-positive macrophages in the adipose tissue of old mice and in the peritoneal cavity of young animals following injection of alginate-encapsulated SCs has raised concerns about the exclusivity of these markers for SCs. Here we report that expression of p16Ink4a and SAβG in macrophages is acquired as part of a physiological response to immune stimuli rather than through senescence, consistent with reports that p16Ink4a plays a role in macrophage polarization and response. Unlike SCs, p16Ink4a/SAβG-positive macrophages can be induced in p53-null mice. Macrophages, but not mesenchymal SCs, lose both markers in response to M1- [LPS, IFN-α, Poly(I:C)] and increase their expression in response to M2-inducing stimuli (IL-4, IL-13). Moreover, interferon-inducing agent Poly(I:C) dramatically reduced p16Ink4a expression in vivo in our alginate bead model and in the adipose tissue of aged mice. These observations suggest that the antiaging effects following eradication of p16Ink4a-positive cells may not be solely attributed to SCs but also to non-senescent p16Ink4a/SAβG-positive macrophages.

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Keywords - aging, macrophage, senescent cell, p16(Ink4a), beta-galactosidase

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at http://www.Aging-US.com​​ and connect with us:

SoundCloud - https://soundcloud.com/Aging-Us

Facebook - https://www.facebook.com/AgingUS/

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Aging-US is published by Impact Journals, LLC: http://www.ImpactJournals.com​​

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Listen to a blog summary of the research paper selected as the cover for Volume 14, Issue 4 of Aging (Aging-US):

Aging seems nearly synonymous with brewing cognitive decline, but does it have to be? There are interventions that may help preserve cognitive function with age, however, the first order of business is identifying early biological aging markers that present before symptoms begin emerging. Mid-life biomarkers that can indicate accelerated aging and predict age-related cognitive decline (including Alzheimer’s disease and dementia) may provide humans with enough time to course-correct and improve our quality of life in old age.

The latest to endeavor in search of these early aging markers are researchers from Northwestern University Feinberg School of Medicine, University of Texas Health Science Center at San Antonio, University of Pennsylvania, Boston University School of Medicine, National Institute on Aging from the National Institutes of Health, University of Minnesota, Columbia University Mailman School of Public Health, Kaiser Permanente Division of Research, University of Texas at Austin, University of California San Francisco, and the San Francisco Veterans Affairs Medical Center. Their new research study was published in Aging (Aging-US) as the cover paper in Volume 14, Issue 4, on February 27, 2022. The paper is entitled, “Mid-life epigenetic age, neuroimaging brain age, and cognitive function: coronary artery risk development in young adults (CARDIA) study.”

Full blog - https://aging-us.org/2022/03/trending-with-impact-cognitive-decline-predicted-from-middle-age/

Paper DOI - https://doi.org/10.18632/aging.203918

Corresponding Authors - Yinan Zheng - [email protected], Kristine Yaffe - [email protected], and Lifang Hou - [email protected]

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Keywords - cognitive function, epigenetic age, brain age, DNA methylation, magnetic resonance imaging

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at http://www.Aging-US.com​​ and connect with us:

SoundCloud - https://soundcloud.com/Aging-Us

Facebook - https://www.facebook.com/AgingUS/

Twitter - https://twitter.com/AgingJrnl

Instagram - https://www.instagram.com/agingjrnl/

YouTube - https://www.youtube.com/agingus​

LinkedIn - https://www.linkedin.com/company/aging/

Pinterest - https://www.pinterest.com/AgingUS/

Aging-US is published by Impact Journals, LLC: http://www.ImpactJournals.com​​

Media Contact

18009220957