In this bonus episode, Howie and Harlan are joined by Ania Jastreboff, a Yale School of Medicine endocrinologist and an expert on the science of obesity. They discuss her new book, co-authored with Oprah Winfrey, which reframes obesity as a treatable disease rooted in biology—not a failure of willpower.

Show notes:

Ania Jastreboff and Oprah Winfrey: Enough: Your Health, Your Weight, and What It's Like To Be Free

Yale Obesity Research Center (Y-Weight)

The Oprah Podcast: "Oprah and Yale Researcher Break Down How Weight Loss Drugs Affect the Brain"

The Oprah Podcast: "Oprah and Dr. Ania Jastreboff on How People Treat You Differently After Weight Loss"

Ania Jastreboff: "Tirzepatide for Obesity Treatment and Diabetes Prevention"

Ania Jastreboff: "Once-Monthly Maridebart Cafraglutide for the Treatment of Obesity — A Phase 2 Trial"

Mayo Clinic: Semaglutide (oral route)

Eli Lilly: What to know about orforglipron: An investigational oral GLP-1

"CagriSema for Weight Loss: Study Results, Availability, and How Other GLP-1s Compare"

Eli Lilly: What to know about eloralintide: An investigational amylin receptor agonist injection

Cleveland Clinic: "Should You Microdose GLP-1 Drugs?"

In the Yale School of Management's MBA for Executives program, you'll get a full MBA education in 22 months while applying new skills to your organization in real time.

Yale's Executive Master of Public Health offers a rigorous public health education for working professionals, with the flexibility of evening online classes alongside three on-campus trainings.

Email Howie and Harlan comments or questions.