This podcast discussed the topic of "Improving consistency and reducing human bias for physicians’ target contouring using AI auto-segmentation." Experts joining the discussion include Steve Jiang, PhD, Professor and Vice Chair in Department of Radiation Oncology at University of Texas Southwestern and Director of Medical Artificial Intelligence and Automation Lab, Nathan Yu, MD, Assistant Professor in Department of Radiation Oncology, Mayo Clinic Arizona, and Yi Rong, PhD, Professor and Lead photon physicist in Department of Radiation Oncology at Mayo Clinic Arizona. This podcast focused on the utility of AI in automatic segmentation of medical imaging and the challenges related to physician variability in clinical practice. We discussed various strategies for addressing these challenges, including developing physician-style aware AI models and balancing standardization with personalization in AI tool development and deployment. The emphasis is on the feasibility and clinical utility of using AI to improve the accuracy and efficiency of medical image segmentation while respecting the art and personalization inherent in clinical medicine.

Editor in Chief Dr. Sue Yom and Associate Editor Dr. Neil Taunk, Assistant Professor of Radiation Oncology and Chief of the Gynecologic Radiation Service at the University of Pennsylvania, co-host a podcast on "Biomarker expression and impact on clinical outcomes in an international study of chemoradiation and MRI-based image-guided brachytherapy for locally advanced cervical cancer: BIOEMBRACE," with guests Dr. Supriya Chopra, Professor at Tata Memorial Centre in Mumbai, India, and Dr. Remi Nout, Professor and Head of the Department of Radiotherapy of the Erasmus Medical Center, University Medical Center, in Rotterdam, Netherlands, who were the first and last authors and both principal investigators of the BIOEMBRACE study.

Editor-in-Chief, Robert Amdur, MD and Resident Physician, Daniela Martir, MD discuss Partially Ablative Body Radiotherapy for Locally Advanced Unresectable Tumor. The discussion is based on a paper in PRO titled “Partially Ablative Body Radiotherapy (PABR): A Widely Applicable Planning Technique for Palliation of Locally Advanced Unresectable Tumors” (PMID 39393770).

Editor-in-Chief Dr. Sue Yom hosts Dr. Mai Anh Huynh, Assistant Professor of Radiation Oncology at the Brigham and Women's Hospital / Dana-Farber Cancer Center who wrote an editorial this month, "The Hidden Benefits of Palliative Radiotherapy: When Radiation of Metastatic Disease is Not "Just" Palliative," Dr. David Palma, a Radiation Oncologist at the London Health Sciences Centre who co-authored, "Ablative Radiation Therapy to Restrain Everything Safely Treatable (ARREST): A Phase I Study of Stereotactic Ablative Radiotherapy for Poly-metastatic Disease", and Dr. Ethan Ludmir, Assistant Professor in the Departments of Gastrointestinal Radiation Oncology and Biostatistics at the University of Texas MD Anderson Cancer Center and supervising author of "Off-Protocol Radiotherapy in Phase III Metastatic Solid Tumor Trials." The group also discusses an article from this month's issue, "Is Local Ablative Stereotactic Radiation Therapy a Valuable Rescue Strategy for Time on Drug in Patients Enrolled in Phase I Trials?"

In this podcast, we discuss the The Society of Thoracic Surgeons/American Society for Radiation Oncology Updated Clinical Practice Guidelines on Multimodality Therapy for Locally Advanced Cancer of the Esophagus or Gastroesophageal Junction. Joining in the discussion are Dr. Stephanie Worrell, Associate Professor and Thoracic Section Chief in the Division of Cardiothoracic Surgery at the University of Arizona College of Medicine, and Dr. Karyn Goodman, Professor and Vice Chair for Research and Quality at the Icahn School of Medicine at Mount Sinai, and Associate Director for Clinical Research at The Tisch Cancer Institute, who served as chair and co-chair of the guideline panel, respectively. Together, we cover important updates and recommendations that incorporate surgical aspects into the multi-disciplinary management of this disease along with practical considerations for everyday practice. Additionally, we discuss in depth the recently presented ESOPEC trial presented at the 2024 ASCO annual meeting and how it has impacted the standard of care for esophageal cancers.

In this podcast, we discuss the The Society of Thoracic Surgeons/American Society for Radiation Oncology Updated Clinical Practice Guidelines on Multimodality Therapy for Locally Advanced Cancer of the Esophagus or Gastroesophageal Junction. Joining in the discussion are Dr. Stephanie Worrell, Associate Professor and Thoracic Section Chief in the Division of Cardiothoracic Surgery at the University of Arizona College of Medicine, and Dr. Karyn Goodman, Professor and Vice Chair for Research and Quality at the Icahn School of Medicine at Mount Sinai, and Associate Director for Clinical Research at The Tisch Cancer Institute, who served as chair and co-chair of the guideline panel, respectively. Together, we cover important updates and recommendations that incorporate surgical aspects into the multi-disciplinary management of this disease along with practical considerations for everyday practice. Additionally, we discuss in depth the recently presented ESOPEC trial presented at the 2024 ASCO annual meeting and how it has impacted the standard of care for esophageal cancers.

Deputy Editor Salma Jabbour hosts Dr. Christopher Anker, Professor of Radiation Oncology and Program Co-Leader in the Cancer Host and Environment program at the University of Vermont Cancer Center, and Dr. Leila Tchelebi, Associate Professor of Radiation Medicine at the Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, respectively the first and second authors of a guideline published in this issue, Executive Summary of the American Radium Society Appropriate Use Criteria for Non-Operative Management for Rectal Adenocarcinoma: Systematic Review and Guidelines

Editor in Chief Dr. Sue Yom co-hosts with Dr. Nicholas Zaorsky, an Associate Editor at the Journal and Associate Professor in the Department of Radiation Oncology at Case Western University Hospitals. We discuss three articles that are publishing rapid online for this meeting including Bladder Adjuvant RadioTherapy (BART): Acute and Late Toxicity from a Phase III Multicenter Randomized Controlled Trial, with the Principal Investigator Dr. Vedang Murthy, Professor in the Department of Radiation Oncology at Tata Memorial Centre in Mumbai, and its accompanying editorial, Adjuvant Radiation Therapy for Locally Advanced Bladder Cancer: A Safe and Promising  Emerging Treatment Option, with first author Dr. Brian Baumann, Radiation Oncologist at Springfield Clinic in Illinois. Relevant to this discussion is a paper appearing in this month's issue, The Value and Safety of Adjuvant Radiation Therapy After Radical Cystectomy in Locally Advanced Urothelial Bladder Cancer: A Controlled Randomized Study and its accompanying editorial, Is It Time to Reconsider the Place of Adjuvant Radiation Therapy After Radical Cystectomy? Finally, our third rapid online paper is Setting the Stage: Feasibility and Baseline Characteristics in the Prostate Advanced Radiation Technologies Investigating Quality of Life (PARTIQoL) Trial Comparing Proton Therapy vs. IMRT for Localized Prostate Cancer, with Principal Investigator Dr. Jason Efstathiou, Professor of Radiation Oncology at Harvard Medical School, Massachusetts General Hospital.

Dr. Sue Yom, Editor in Chief, hosts Ms. Nina Levin, a Medical Physicist and PhD Candidate and Dr. Bjørn Grønberg, Professor and Consultant in medical oncology and radiotherapy, from the Department of Clinical and Molecular Medicine at the Norwegian University of Science and Technology, and Dr. Megan Daly, Professor from the University of California Davis and an Associate Editor at our journal. We discuss Ms. Levin’s and Dr. Grønberg’s article, Evaluation of radiotherapy treatment plans in a randomized phase II trial comparing two schedules of twice-daily thoracic radiotherapy in limited stage small-cell lung cancer, and its accompanying editorial, Toward the Optimal Delivery of Twice-Daily Thoracic Chemoradiation in Limited-Stage Small Cell Lung Cancer, as well as an article from the August 2024 issue, Long-Term Outcomes After Concurrent Once- or Twice-Daily Chemoradiation in Limited-Stage Small Cell Lung Cancer: A Brief Report From the CONVERT Trial.

Ronald Chen, MD, MPH, FASTRO, hosts a conversation on the background, methodology, primary recommendations, and implications of the updated External Beam Radiation Therapy for Palliation of Symptomatic Bone Metastases: An ASTRO Clinical Practice Guideline. Alongside Tracy Balboni, MD, MPH, and Sara Alcorn, MD, they discuss recent data and changes to practice patterns such as increased use of advanced treatment approaches (e.g., stereotactic radiation) and reirradiation. The guidelines address five key questions in this context, built upon a systematic review of the available literature and with assessment of evidence quality and recommendation strength.