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Editor in Chief Dr. Sue Yom co-hosts with Biology Editor Dr. Henning Willers, Associate Professor at Harvard Medical School and Director of Translational Radiation Research at Mass General Brigham, welcoming our guest Dr. Pippa Cosper, Assistant Professor in the Department of Human Oncology at the University of Wisconsin. Dr. Cosper discusses her first-author article published in this month’s issue, “Pretreatment Chromosomal Instability Correlates With Radiation Sensitivity in Squamous Cell Cancers.”

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Editor-in-Chief Sue Yom hosts Associate Editor Dr. Sara Alcorn, Associate Professor, Vice Chair of Clinical Strategy, and Director of Palliative Care at the University of Minnesota; Michael Shing Fung Lee, Consultant in the Department of Radiation Oncology at National University Cancer Institute and Clinical Senior Lecturer at the National University Hospital Singapore; and Dr. Henry Wong, Clinical Research Fellow in Radiation Medicine Program at the Princess Margaret Cancer Centre. They co authored the article, “Translating Evidence to Practice: Advancing Equitable Access to Dermatologic Care for Radiation Dermatitis Worldwide.”

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The role for radiation in the management of gastric cancer is evolving, given developments in systemic therapy.  ASTRO has released updated guidelines to provide evidence-based expert consensus on where radiation fits in the modern management of this disease.  This PRO podcast from Drs. Michael Buckstein, MD, PhD, Salma Jabbour, MD, and Christopher Anker, MD will help you navigate these guidelines and also explore some of the grey areas in gastric cancer where radiation can still make a big impact in this cancer.  

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Dr. Sue Yom, Editor in Chief, co-hosts with Section Editor Dr. Kilian Salerno, Associate Research Physician at the United States’ National Cancer Institute Radiation Oncology Branch, discussing this month’s Oncology Scan, “Proton beam radiotherapy for all children and adolescents globally: Is this a realistic and cost-effective goal?” Guests include Dr. Jeannette Parkes, Head of Radiation Oncology and Radiation Medicine at Groote Schuur Hospital at the University of Cape Town in South Africa; Dr. Natia Esiashvili, Professor in the Department of Radiation Oncology at Emory University; and Dr. Derek Tsang, Clinician Investigator at Princess Margaret Cancer Centre and Associate Professor in the Department of Radiation Oncology at the University of Toronto.

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Editor-in-Chief Sue Yom hosts three editors who pick highlights from the special issue! Dr. Nicholas Zaorsky is Professor in the Department of Radiation Oncology at Case Comprehensive Cancer Center and Vice Chair of Education and Director of Genitourinary Oncology at University Hospitals in Cleveland. Dr. Michelle Kim, Professor in the Department of Radiation Oncology and Co-Chair of the Cancer Center Neuro-Oncology Clinical Research Team at the University of Michigan, is the section chief for Brain and Spine at the Red Journal. Dr. Bethany Anderson, Professor at the University of Wisconsin School of Medicine and Public Health in the Department of Human Oncology and specialist in breast and gynecologic cancer treatment, is our Breast cancer section editor. 

Dr. Zaorsky’s picks are: Stereotactic Body Radiation Therapy to the Prostate With Focal Boost: Analysis of the Primary Endpoint in the DELINEATE Trial Cohort E; PSMA-PET-Guided Intraprostatic Boost in Prostate SBRT (PROBE): A Phase 2 Trial; Two-Year Outcomes of the SPARC Phase II Trial: Simultaneous Focal Boost With Stereotactic Radiation Therapy for Localized Prostate Cancer; The Kilovoltage Intrafraction Monitoring Real-Time Prostate Cancer Image Guided Radiation Therapy Technology Journey: From Clinical Trials to Your Clinic; International Radiosurgery Oncology Consortium of the Kidney (IROCK) Contouring Guidelines for Renal Cell Carcinoma Treated With Stereotactic Ablative Radiation Therapy; Stereotactic Body Radiation Therapy for Renal Tumors: A Prospective Phase 2 Clinical Trial; Efficacy of SABR in Uncommon Subtypes of Primary Kidney Cancer: An Analysis From the International Radiosurgery Oncology Consortium of the Kidney; SABR Versus Radiofrequency Ablation and Cryoablation for Primary Renal Cell Carcinoma: An Economic Evaluation of the FASTRACK II Trial; A Prospective Study of Stereotactic Body Radiation Therapy in Oligometastatic Renal Cell Carcinoma; and Stereotactic Body Radiation Therapy for Oligoprogressive Disease in Androgen-Suppressed Prostate Cancer: Primary Endpoint Analysis of the TRAP Trial.

Dr. Kim’s picks are: Long-term Results From a Phase 1 Study of Spinal Cord Constraint Relaxation With Single Session Spine Stereotactic Radiosurgery in the Primary Management of Patients With Inoperable, Previously Unirradiated Spinal Metastases With Epidural Extension; Direct-to-Unit Stereotactic Magnetic Resonance Imaging-Guided Adaptive Radiation Therapy for Spine Metastasis; Treatment With Stereotactic Ablative Radiation Therapy for Patients With up to 5 Oligometastatic Cancer Lesions: Long-Term Outcomes of the Nonrandomized Population-based Phase 2 SABR-5 Clinical Trial; and Evaluating Toxicity and Interaction Outcomes of Systemic Therapy and Stereotactic Ablative Radiation Therapy for Oligometastatic Disease: A Secondary Analysis of the Phase 2 SABR-5 Trial.

Dr. Anderson’s picks are: A Study of Curative-approach Treatment Along With Metastasis-Directed Stereotactic Body Radiation Therapy in Bone-Only Oligometastatic Breast Cancer; Long-Term Results of a Phase 2 Prospective Clinical Trial of Single-Fraction, High-Gradient Adjuvant Partial Breast Irradiation in Early-Stage, Hormone-Positive Breast Cancer; and Postoperative Single-Fraction Stereotactic Partial Breast Irradiation for Early-Stage Breast Cancer With GammaPod Technology: A Phase 2 Clinical Trial.

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Deputy Editor Dr. David Palma hosts four authors from our SBRT Clinical Trials special issue: Dr. Anand Swaminath, Associate Professor at McMaster University and supervising author of “Quality of Life of Stereotactic Versus Hypofractionated Radiation Therapy for Inoperable Stage I Non-Small Cell Lung Cancer: Results From the LUSTRE Trial”; Dr. Kristin Karlsson, Medical Physicist at Karolinska University Hospital and first author of “Dose-Volume Predictors of Fatal Bronchopulmonary Bleeding After Stereotactic Body Radiation Therapy of Centrally Located Lung Tumors: An Analysis of the Expanded HILUS Cohort”; Dr. Alexa Dang, Radiation Oncologist at BC Cancer Vancouver and first author of “Dosimetric Outcomes for Stereotactic Radiation Therapy in Early-Stage Non-Small Cell Lung Cancer and Interstitial Lung Disease: A Secondary Analysis of the ASPIRE-ILD Trial”; and Dr. Fabio Arcidiacono, Radiation Oncologist at S. Maria Hospital and first author of “Five-Year Survival and Safety of SABR in Patients with Unresectable Locally Advanced Non-Small Cell Lung Cancer unfit for Concurrent Radiochemotherapy: Focus on Patterns of Local Recurrence from the START-NEW-ERA Non-randomized Phase 2 Trial.”

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Editor-in-Chief Sue Yom hosts Dr. David Cooke, Physician-in-Chief at UC Davis Comprehensive Cancer Center, Professor and Founding Chief of the Division of General Thoracic Surgery, and Task Force Chair of the UC Davis Comprehensive Lung Cancer Screening Program; Dr. Ella Kazerooni, Director of Cardiothoracic Radiology, Chair of the Radiology Service Excellence Program at the University of Michigan, and executive sponsor of lung cancer screening at the American College of Radiology; and Dr. Drew Moghanaki, Professor and Chief of Thoracic Radiation Oncology at UCLA who previously led the the VA Partnership to Increase Access to Lung Screening, discussing the co-authored multisociety statement, “Misinformation and Overestimation of Computed Tomography Lung Cancer Screening Harms—Methodology Matters: A Joint Statement from The Society of Thoracic Surgeons, the American Society for Radiation Oncology, and the American College of Radiology.”

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ASTRO has recently updated guidelines for WHO Grade 4 Adult-Type Diffuse Glioma Guideline to align practice with outcomes from multiple newly published studies for higher grade gliomas published over the past decade. This podcast, led by Dr. Majid Al-Othman, features lead authors of the new ASTRO WHO Grade 4 Adult Glioma guidelines Dr. Debra Nana Yeboa, MD and Dr. Joseph Bovi, MD representing the guideline team of co-authors. It highlights the main questions answered by the new guidelines, changes in the molecular definition of gliomas, as well as ASTRO methodology for consensus building and lingering questions to be addressed. 

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Editor-in-Chief Sue Yom hosts Dr. Dan Golden, Associate Professor and Vice Chair for Education in the Department of Radiation Oncology at Rush University Medical Center and the author of an essay in this month’s Real Talk on Wellness section, “After Burnout: Reigniting the Flame”; Dr. Marie Soller, Associate Professor in the Department of Psychiatry at the Oregon Health and Science University and author of one of our first RTOW essays, “Self-Compassion and Help Seeking in Medicine”; and Dr. David Feldman, Professor of Counseling Psychology at Santa Clara University, current Visiting Professor at Chulalongkorn University in Bangkok, and co-author of an essay just published online, “Hope Mapping as a Tool for Mitigating Burnout in Radiation Oncology.”

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Editor-in-Chief Dr. Sue Yom hosts Dr. June Corry, Radiation Oncologist at GenesisCare, Fitzroy, at St Vincent's Hospital, prior Chair of the NPC committee of the Trans Tasman Radiation Oncology Group’s project ANROTAT, Assessment of New Radiation Oncology Technology and Treatments, and first author of a new article, “Can Radiotherapy Quality Assurance improve nasopharyngeal cancer outcomes in low- and middle-income countries – Reporting the technical component of the second phase of a prospective International Atomic Energy Agency study.” We also host the last author, Dr. Anne Lee, Head of the Center of Clinical Oncology at the University of Hong Kong-Shenzhen Hospital in China. She was previously the Head of the Clinical Oncology Department of the University of Hong Kong and the Deputy Hospital Chief Executive of the Shenzhen Hospital. Dr. Lee has led the development of many important NPC delineation and planning guidelines, including several published in the Red Journal.