Executive Editor Michael Roy speaks with Thorhildur Halldorsdottir, Ph.D., and Elisabeth Binder, M.D., Ph.D., about their research on predicting depression outcomes in youths and how the interaction between FKBP5, a gene involved in regulating the stress system, and early-life exposure to intimate partner violence affects the physiological response to stress early in life, with consequences for emotional and cognitive development.

• How polygenic risk scores may be used to identify risk for and symptoms of depression in young people [3:32]
• The interaction between exposure to stress in early life and emotional and cognitive development [8:05]
• Key points from each study [10:26]
• Applying gene-by-environment research to real-world work [14:27]
• What lies ahead in the study of how genes and the environment interact to influence mental health [16:34]

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