The Top Line

August 5, 2022


Listen Later

It's earnings season—a time when publicly traded pharmas and biotechs tell their investors how they've performed over the previous quarter. But aside from drug sales figures, it’s a great opportunity to get a sense of how these companies' pipelines have changed. We'll dig into that, and even the stuff that companies are less keen to talk about. 

Regeneron once boasted one of the top COVID-19 therapeutics in its antibody cocktail REGEN-COV. Now, the company is terminating four studies for the med across a range of patients and clinical stages. The move follows the FDA’s decision to pull the medication from the market in January, citing uncertain efficacy against the surging omicron variant. And Regeneron’s antibody combo isn’t alone. We'll discuss how early pandemic therapeutics have fallen by the wayside.

To learn more about the topics in this episode: 

  • AstraZeneca axes Moderna-partnered, phase 2 heart disease drug plus a Wee inhibitor
  • BMS-Ambrx collab runs out of steam after FA relaxin med canned
  • Takeda cuts ties to cancer drug landed in $120M Turnstone deal
  • The NASH curse strikes again. Pfizer dumps early-stage asset for liver condition
  • AstraZeneca axes Moderna-partnered, phase 2 heart disease drug plus a Wee inhibitor
  • PerkinElmer to rebrand as life-science-focused supplier, sell off other businesses in $2.45B deal
  • Merck's Keytruda, on a losing streak, fails in once FDA-rejected liver cancer use and prostate cancer—again
  • Bristol Myers' Opdivo-Yervoy combo joins Roche on the postsurgery kidney cancer flop list
  • Axcella misses primary endpoint in long COVID trial but plots path to market based on fatigue scores
  • Bose abandons hearing aid plans, hands off direct-to-consumer tech to Lexie Hearing
  • We're looking for 2022's Fiercest Women in Life Sciences
  • The Top Line is produced by senior multimedia producer Teresa Carey with editor-in-chief Tracy Staton, managing editor Querida Anderson and senior editors Annalee Armstrong, Ben Adams, Conor Hale and Eric Sagonowsky. The sound engineer is Caleb Hodgson. The stories are by all our “Fierce” journalists. Like and subscribe wherever you listen to your podcasts.

    See omnystudio.com/listener for privacy information.

    ...more
    View all episodesView all episodes
    Download on the App Store

    The Top LineBy Fierce Life Sciences

    • 3.8
    • 3.8
    • 3.8
    • 3.8
    • 3.8

    3.8

    8 ratings


    More shows like The Top Line

    View all
    WSJ Your Money Briefing by The Wall Street Journal

    WSJ Your Money Briefing

    1,753 Listeners

    The McKinsey Podcast by McKinsey & Company

    The McKinsey Podcast

    381 Listeners

    a16z Podcast by Andreessen Horowitz

    a16z Podcast

    1,034 Listeners

    Exchanges by Goldman Sachs

    Exchanges

    991 Listeners

    Odd Lots by Bloomberg

    Odd Lots

    1,789 Listeners

    Macro Musings with David Beckworth by Mercatus Center at George Mason University

    Macro Musings with David Beckworth

    375 Listeners

    The Long Run with Luke Timmerman by Timmerman Report

    The Long Run with Luke Timmerman

    122 Listeners

    The Readout Loud by STAT

    The Readout Loud

    318 Listeners

    Inside the Strategy Room by McKinsey & Company

    Inside the Strategy Room

    171 Listeners

    Why It Matters by Council on Foreign Relations

    Why It Matters

    876 Listeners

    Business Of Biotech by Ben Comer

    Business Of Biotech

    88 Listeners

    BioCentury This Week by BioCentury

    BioCentury This Week

    29 Listeners

    Raising Health by Andreessen Horowitz, a16z Bio + Health

    Raising Health

    147 Listeners

    Biotech Hangout by Daphne Zohar, Josh Schimmer, Brad Loncar, Tim Opler & more

    Biotech Hangout

    10 Listeners

    Ground Truths by Eric Topol

    Ground Truths

    51 Listeners