There is a growing new mood in science. The grip that scientific materialism has had on the scientific imagination is beginning to loosen. This is the philosophy that all things in the natural world can be reduced to the material level. But it seems as if the many everyday experiences that individuals have, in particular being conscious, which can't be accounted for by physicalism are forcing the possibility of considering alternatives. In this dialogue, Rupert Sheldrake and Mark Vernon consider what might be happening, how such a shift would make a difference in areas from health to parapsychology, and what might happen next.