Caloric restriction. Blood transfusions. Hormetic stress. Off-label meds. As CNN’s Chief Medical Correspondent, Dr. Sanjay Gupta is often asked about the latest “hacks” for longevity that pop up in the news. But do any of these interventions actually work? Can aging actually be stopped, much less reversed? In this episode, Sanjay speaks with Dr. Nir Barzilai, the director of the Institute for Aging Research at the Albert Einstein College of Medicine. He believes one of the keys to battling aging lies in our cells and genetic makeup. Plus, we hear from self-professed “biohackers,” who have some tips we can all try to extend our healthy years.

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