In this episode of Breaking the Silence from APA's More Equity in Mental Health series, Dr. Laika Rose Simeon-Thompson sits down with child and adolescent psychiatrist Dr. Anjali Gupta to explore how depression affects teen girls and young women. Dr. Gupta explains what is happening in the adolescent brain, how social media and generational trauma shape risk, and why supportive schools, families, and mentors can be lifesaving. They also discuss barriers to care, what emergency departments are seeing on the front lines, and practical messages for parents, educators, and communities that want to show up for girls in crisis. Listeners will come away with a clearer understanding of both the vulnerabilities and the strengths of this generation of young women.