Actor Jeffrey Tambor talks about his portrayal of Jesse's favorite television character — Hank Kingsley on The Larry Sanders Show. Then, an interview with Doug Jones. He's tall and skinny, with a skinny face. His physicality and mime training have informed his performances in prosthetics for Hellboy, Pan's Labyrinth and the Silver Surfer. Plus, Andrew Noz suggests the rap songs you should check out this week and God speaks out about what REALLY went down with Noah and the ark.

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Keegan-Michael Key & Jordan Peele talk about their comedy beginnings on MADtv; impersonating everyone from presidents, to weather men, to gang members on their new Comedy Central show; and a card game that Jordan Peele designed himself! Plus, Jesse faces a gaming obsession of his own and the Brothers McElroy solve listeners' pop culture quandaries.

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This week David Wain makes the successful leap from cultiest-of-cult comedy to the mainstream multiplex – and keeps things super funny. Correspondant Jordan Morris ranks all of the things in America because we told him to. Plus, the AV Club offers some of their all-time favorite culture picks, and Jesse talks about his JAM — DJ Quick's Pitch In Ona Party.

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Daniel Handler delves into his memories of young love to pen the novel "Why We Broke Up" — the twist? He writes the girl's side of the story. The Sklar Brothers talk about their new comedy album – from performing as identical twins to broadening their sports-nerd base. Plus Jesse suggests the Canadian TV show The Newsoom, Mark Frauenfelder of Boing Boing brings his recommendations and American composer Nico Muhly shares the song that changed his life.

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Actor Michael Rapaport profiles his favorite hip-hop group, A Tribe Called Quest, and ends up documenting their deep-rooted friendships and conflicts. Filmmaker Werner Herzog looks into the Chauvet Caves of France, where the oldest known cave paintings exist, practically untouched over thousands of years. Plus, AV Club offer their culture recommendations, Jesse suggests you listen to Sly Stone's "If You Want Me To Stay" and comedy group Kasper Hauser make up the news.

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Tim and Eric are known for the surreal and uncomfortable comedy in their sketch show Tim and Eric Awesome Show, Great Job!. They also promoted Shrek 3 without permission from the movie studio. Now, they've made a billion dollar movie of their own. Cartoonist Roz Chast explains some of her day-to-day fears like balloons, water, and sitting on the ground. Plus a section from God's memoir (as dictated to comedy writer David Javerbaum) and Jesse suggests Randy Newman in his outshot.

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Jenna Fischer talks about her totally-made-up-sounding first acting gig in LA, auditioning for The Office, and what all the actors are doing on their computers when they're in the background of a shot. The very real Jack Handey talks about his days as Steve Martin's neighbor, and how he writes Deep Thoughts. Plus this week's video game recommendations from Heather Anne Campbell and more!

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Aisha Tyler funnels her childhood outsider-y experiences toward comedy and performance. She's on the animated FX show Archer. David Hornsby talks about building comedic stories from his real life relationships. His new animated FX show is called Unsupervised. Plus, the AV Club shares their recommendations and Jordan Morris puts America in its place ... by ranking everything.

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In a supplement to this week's interview, Lawrence Weschler talks with Jesse about The Museum of Jurassic Technology. Don't miss this!

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Jesse interviews comedian Chris Gethard about booking P. Diddy at a tiny theater in New York. Lawrence Weschler talks about why CGI faces will never look quite right, and why humans are addicted to narrative. Plus rap picks from Andrew Noz and pop culture advice from My Brother, My Brother and Me.

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