For over 50 years, the standard has been that Staph aureus bacteremia and endovascular infections must be treated with a bactericidal antibiotic, like beta lactams or vancomycin. A new study suggests that bacteriostatic antibiotic, like clindamycin, could be used to treat MRSA bacteremia.

Redeem your CPE or CME credit here!

References and resources: Guthridge I, Smith S, Law M, et al. Efficacy and Safety of Intravenous Lincosamide Therapy in Methicillin-Resistant Staphylococcus aureus Bacteremia. Antimicrob Agents Chemother. 2021 Aug 17;65(9):e0034321. doi: 10.1128/AAC.00343-21. Epub 2021 Aug 17. PMID: 34125589.


Continuing Education Information:
Learning Objectives:
1. Identify if an uncomplicated patient with MRSA bacteremia may be eligible for bacteriostatic medications
2. Describe some of the advantages of using drugs like clindamycin in these patients

0.05 CEU | 0.5 Hrs
ACPE UAN: 0107-0000-21-339-H01-P
Initial release date: 10/12/21
Expiration date: 10/12/2022
Complete CPE & CME details can be found here !

What's new?

• GameChangers Pharmacotherapy Podcast will release new episodes on Mondays starting 10/18/2021
• We are making it easier to claim CE Credit for listening each week! This October - we'll launch a simple, one membership option so you can get one-click CE redemption for GameChangers episodes.  
• Name changes! You'll notice the podcast show will change to CEimpact - you'll still get new GameChangers episodes released each week on Mondays. Keep listening here and your feed will automatically switch over to CEimpact on 10/18.

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Can a ‘report card' tame excessive prescriptions of antibiotics in outpatient settings? In this episode Dr. Wall with guest Josh Yost, MD, FACP will evaluate a paper that looked at using 'report cards' on antibiotic use and its impact on outpatient prescribing.

Guest:
W. John Yost, MD, FACP
UnityPoint Health

Earn CME or CPE credit here!

References and resources: Schwartz KL, Ivers N, Langford BJ, et al. Effect of Antibiotic-Prescribing Feedback to High-Volume Primary Care Physicians on Number of Antibiotic Prescriptions: A Randomized Clinical Trial. JAMA Intern Med. Published online July 06, 2021. doi:10.1001/jamainternmed.2021.2790

Continuing Education Information:
Learning Objectives:
1. Discuss the implementation of a report card to educate primary care providers on overuse of antibiotics
2. Discuss issues related to implementation of the study methods to other health systems and the potential costs that could be saved in doing so

0.05 CEU | 0.5 Hrs
ACPE UAN: 0107-0000-21-306-H01-P
Initial release date: 9/7/21
Expiration date: 9/7/22
Dr. Yost reports no actual or potential conflicts of interest associated with this activity.
Complete CPE & CME details can be found here.

What's new?

• GameChangers Pharmacotherapy Podcast will release new episodes on Mondays starting 10/18/2021
• We are making it easier to claim CE Credit for listening each week! This October - we'll launch a simple, one membership option so you can get one-click CE redemption for GameChangers episodes.  
• Name changes! You'll notice the podcast show will change to CEimpact - you'll still get new GameChangers episodes released each week on Mondays. Keep listening here and your feed will automatically switch over to CEimpact on 10/18.

Follow CEimpact on Social Media:
LinkedIn
Instagram

Anti-mask and anti-vaccine fervor are causing an overload of the healthcare system and leading to increased mortality and morbidity. Three publications recently released, including a randomized controlled trial, evaluate community masking on COVID-19 spread.

Guest
Michael Hogue, PharmD, FAPhA, FNAP
Dean, Loma Linda University

Redeem your CPE or CME credit here!

References and resources: Abaluck J, Kwong L, Styczynski A, et al. The Impact of Community Masking on COVID-19: A Cluster-Randomized Trial in Bangladesh. Available at: https://www.poverty-action.org/publication/impact-community-masking-covid-19-cluster-randomized-trial-bangladesh. Bazant M, Bush J. A guideline to limit indoor airborne transmission of COVID-19. Proceedings of the National Academy of Sciences Apr 2021, 118 (17) e2018995118; DOI: 10.1073/pnas.2018995118. Center for Disease Control. Morbidity and mortality weekly report: MMWR. [Atlanta, GA]: US Dept of Health, Education, and Welfare, Public Health Service, Center for Disease Control. Sept 10, 2021.


Continuing Education Information:
Learning Objectives:
1. Describe the Abaluck et al trial, including benefits and applications
2. Describe the evidence base for public health interventions, including difficulties for randomized controlled studies

0.05 CEU | 0.5 Hrs
ACPE UAN: 0107-0000-21-338-H01-P
Initial release date: 09/28/21
Expiration date: 09/28/22
Dr. Hogue reports no actual or potential conflicts of interest associated with this activity.
Complete CPE & CME details can be found here!

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The recent ESCAPED study examines the treatment of Vaso-occlusive Crisis (VOC) in persons with Sickle Cell Disease (SCD). Many patients have difficulty receiving treatment due to a myriad of factors, including structural racism. Listen as Geoff examines if the ESCAPED study can shine a light on how to treat VOC in patients with SCD.

Redeem your CPE or CME credit here!

References and resources:
Lanzkron S, Little J, Wang H, et al. Treatment of Acute Pain in Adults With Sickle Cell Disease in an Infusion Center Versus the Emergency Department : A Multicenter Prospective Cohort Study. Ann Intern Med. 2021 Jul 6. doi: 10.7326/M20-7171. Epub ahead of print. PMID: 34224261.

Continuing Education Information:
Learning Objectives:
1. Describe the guideline goals for treatment of Vaso-occlusive Crisis (VOC) to a specific patient
2. Discuss the results of the ESCAPED study in relation to outcomes

0.05 CEU | 0.5 Hrs
ACPE UAN: 0107-0000-21-286-H01-P
Initial release date: 8/24/21
Expiration date: 8/24/22
Complete CPE & CME details can be found here.

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Recent studies have suggested that a short course of antibiotics, compared to longer durations, are just as efficacious for many common infections. The appropriate duration of urinary tract infections for men, by definition complicated, is uncertain due to the risk of developing secondary prostatitis. A new study evaluates 7 vs 14 days of antibiotic treatment of UTIs in men without fever.

Redeem your CPE or CME credit here!

References and resources: Drekonja DM, Trautner B, Amundson C, Kuskowski M, Johnson JR. Effect of 7 vs 14 Days of Antibiotic Therapy on Resolution of Symptoms Among Afebrile Men With Urinary Tract Infection: A Randomized Clinical Trial. JAMA. 2021;326(4):324–331. doi:10.1001/jama.2021.9899

Continuing Education Information:
Learning Objectives:
1. Describe the potential complications of urinary tract infections in men that are different than women
2. Implement the findings of this study into a clinical practice

0.05 CEU | 0.5 Hrs
ACPE UAN: 0107-0000-21-316-H01-P
Initial release date: 9/14/21
Expiration date: 9/14/22
Complete CPE & CME details can be found here!

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The United States Preventative Services Task Force (USPSTF) announced new recommendations for diabetes screening. Approximately 34.5% of the US population has pre-diabetes – frequently attributed to the 75% of US adults with an overweight or obese body mass index. What makes 35 years old the new test screening age for diabetes compared to 40?

Guest:
John A Galdo, PharmD, MBA, BCPS, BCGP
Course Content and Developer, CEimpact
Pharmacist, Ross Bridge Pharmacy
CEO, Seguridad

Redeem your CPE or CME credit here!

References and resources: US Preventive Services Task Force. Screening for Prediabetes and Type 2 Diabetes: US Preventive Services Task Force Recommendation Statement. JAMA. 2021;326(8):736–743. doi:10.1001/jama.2021.12531

Continuing Education Information:
Learning Objectives:
1. Identify individuals who should be screened for diabetes
2. Describe the role of racial and ethnic disparities in diabetes

0.05 CEU | 0.5 Hrs
ACPE UAN: 0107-0000-21-323-H01-P
Initial release date: 9/07/21
Expiration date: 9/07/22
John A. Galdo reports that he is on a speaker's bureau for Novo Nordisk.
Complete CPE & CME details can be found here

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Proton Pump Inhibitors (PPIs), like all drugs, cause adverse drug events. Given the sheer number of patients prescribed, or using over-the-counter, PPIs, many practitioners may question continued use. Hear as Geoff examines a recent study from Ann Arbor which looked at the effects of a deprescribing program to step down from PPIs.

Redeem your CPE or CME credit here by getting a GameChangers Subscription!

References and resources:
N/A

Continuing Education Information:
Learning Objectives:
1. Discuss a recent study evaluating the risks of proton pump inhibitors
2. Identify potential patients that could benefit from proton pump inhibitor discontinuation

0.05 CEU | 0.5 Hrs
ACPE UAN: 0107-0000-21-232-H01-P
Initial release date: 8/10/21
Expiration date: 8/10/22
Complete CPE & CME details can be found here.

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The Delta variant has made it clear the COVID pandemic is far from over. Recent studies have suggested that immunocompromised patients may have a reduced or no antibody response to the currently available COVID-19 vaccines. On August 13th, the CDC and FDA recommended that patients receive an additional vaccination. Hear Dr. Geoff Wall and guest, Dr. Nicole Alvey, on how immunocompromised patients need an additional dose, and how to prioritize their care. Drs. Wall and Alvey also share preliminary thoughts on booster vaccines based on the U.S. Surgeon General’s announcement on 8.18.21 recommending booster shots available at 8 months; however, the Biden administration announced on 8.25.21 that booster shots should be available after 6 months of the last dose, pending ACIP review.

Guest:
Nicole Alvey, PharmD, BCPS, FAST
Associate Professor, Roosevelt University

Earn CME or CPE credit with a GameChangers Subscription!

Want more? Head over to The Pharmacy Network to watch our Expert in Residence discuss all things COVID-19 boosters + additional shots titled All About Boosters.

References and resources:

Continuing Education Information:
Learning Objectives:
1. Describe risk factors for having a poor antibody response to currently available COVID-19 vaccines
2. Implement new recommendations for an additional vaccination of COVID-19 in eligible patients

0.05 CEU | 0.5 Hrs
ACPE UAN: 0107-0000-21-XXX-H06-P
Initial release date: 8/24/21
Expiration date: 9/7/22
Dr. Alvey reports no actual or potential conflicts of interest associated with this activity.
Complete CPE & CME details can be found here.

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A landmark paper published in 2002 set the standard for Targeted Temperature Management (TTM)  by having hospitals use TTM protocols to "cool" patients for a period of time after cardiac arrest to improve neurologic outcomes. On June 17th, 2021, the TTM-2 study was published and changed this standard. What is the future of the TTM modality in cardiac arrest patients?

Redeem your CPE or CME credit here!

References and resources:
Dankiewicz J, Cronberg T, Lilja G, et al. Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest. N Engl J Med. 2021 Jun 17;384(24):2283-2294. doi: 10.1056/NEJMoa2100591. PMID: 34133859.

Continuing Education Information:
Learning Objectives:
1. Describe the TTM-2 study
2. Discuss the theoretical benefits of maintaining a normal or low body temperature immediately following cardiac arrest.

0.05 CEU | 0.5 Hrs
ACPE UAN: 0107-0000-21-263-H01-P
Initial release date: 8/17/21
Expiration date: 8/17/22
Complete CPE & CME details can be found here.

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Do psychedelics treat mental illness? In this GameChanger episode host, Geoff Wall and guest, Sarah Grady, a psychiatric pharmacist, discuss a recent NEJM article comparing psilocybin (magic mushrooms) to escitalopram.

Guest:
Sarah Grady, PharmD
Drake University

Redeem your CPE or CME credit here with your GameChangers Subscription!

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References and resources:
Carhart-Harris R, Giribaldi B, Watts R, et al. Trial of Psilocybin versus Escitalopram for Depression. N Engl J Med. 2021 Apr 15;384(15):1402-1411. doi: 10.1056/NEJMoa2032994. PMID: 33852780.

Continuing Education Information:
Learning Objectives:
1. Discuss a recent study comparing psilocybin to escitalopram in depression
2. Identify potential patients that could benefit from psilocybin based on the study

0.05 CEU | 0.5 Hrs
ACPE UAN: 0107-0000-21-231-H01-P
Initial release date: 8/3/21
Expiration date: 8/3/22
Dr. Sarah Grady reports no actual or potential conflicts of interest associated with this activity.
Complete CPE & CME details can be found here.

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