Clinician's Roundtable

Host: Larry Kaskel, MD

Guest: Lawrence Rudel, PhD

Dr. Larry Rudel joins Dr. Larry Kaskel to discuss the enzyme ACAT2 and its confirmed relationship with LDL. Dr. Rudel's new study in mice raises a tantalizing possibility. By inhibiting ACAT2, will we one day be able to eat any kind of fat we want without raising our risk of heart disease?

Host: Michael Benson, MD

Guest: Christopher Plowe, MD, MPH

In this segment, Dr. Plowe describes the current state of malarial control on a global level. By his account, physicians and the general public do have good tools for control including effective treatments, bed nets, intermittent preventive treatments, indoor residual spraying (e.g. DDT), and good progress on vaccines. The challenge, however, is to make proper use of what is available, which is a sentiment amplified a thousand-fold when exploring the state of endemic regions of the world.

Host: Michael Benson, MD

Guest: Christopher Plowe, MD, MPH

In this segment, Dr. Plowe describes the malarial preventive treatments and travel-precautionary strategies applied for patients, including chemoprophylaxis, mosquito abatement methods, and chemical repellants such as DDT and Silent Spring. The interview concludes with an examination of natural immunity to malaria and the question on whether some people who live in endemic areas still need prophylaxis.

Host: Michael Benson, MD

Guest: Christopher Plowe, MD, MPH

In this segment, Dr. Plowe overviews the diagnostic and therapeutic modalities for malaria, as well as the current states of resistance, comparatively on national vs. global levels. The stark discrepancies in available resources for treatment and prevention become quickly apparent as Dr. Plowe describes personal experiences facing total lack of access to health care in large parts of sub-Saharan Africa.

Host: Michael Benson, MD

Guest: Christopher Plowe, MD, MPH

In this segment, Dr. Plowe describes the pertinent biological features of malarial infection and the scope of malaria's impact on a global level. Many physicians are surprised to learn that between one and three million people continue to die each year secondary to this disease. The interview revisits familiar concepts such as the parasitic life cycles and types of mosquitoes responsible for transmission, and then follows with clinical pearls on malarial disease course and presenting symptoms.

Host: Larry Kaskel, MD

Guest: Stephen Nicholls, PhD

The ASTEROID investigated the impact of high-dose rosuvastatin therapy on the rate of atheroma progression in patients with coronary artery disease.

Host: Bill Rutenberg, MD

Guest: Margaret Bauman, MD

Dr. Bauman explores how a family adjusts when a child has been diagnosed with autism.

Host: Leslie P. Lundt, MD

Guest: Jennifer Lynch, MD

Dr. Lynch explains what is known about the neurobiology of sleep.

Host: Leslie P. Lundt, MD

Guest: Jennifer Lynch, MD

Dr. Jennifer Lynch explores how changes in sleep occur with neurodegenerative disease, and what to look for in your patients.

Host: Leslie P. Lundt, MD

Guest: Jennifer Lynch, MD

Dr. Jennifer Lynch identifies common causes of insomnia in the elderly.