The CAUGHT-CAD randomized clinical trial sought to determine whether a CAC score-informed strategy could slow the progression of coronary plaque volume. Author Thomas H. Marwick of the Baker Heart & Diabetes Institute joins JAMA Associate Editor Pradeep Natarajan to discuss "Effects of Combining Coronary Calcium Score With Treatment on Plaque Progression in Familial Coronary Artery Disease." Related Content:

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• Coronary Artery Calcium Testing—Too Early, Too Late, Too Often
• Filling the Evidence Gaps Toward a Coronary Artery Calcium-Guided Primary Prevention Strategy