In this “Breathe Easy Critical Perspective” podcast, Dr. Dominique Pepper interviews Dr. Christopher Hughes. They discuss the 2021 NEJM February article that investigated the use of propofol vs. dexmedetomidine for sedation in mechanically ventilated adults with sepsis. Dr. Hughes serves as Chief of the Anesthesia Critical Care Medicine Division, as Medical Director of the Neuro ICU, and as a member of the VUMC Institutional Review Board at Vanderbilt University Medical Center, Nashville TN.