When Chanania, Mishael and Azaria were saved from the fiery furnace, it shed a bad light on the rest of the Jews, as the gentiles said, if their God is so great, how can the rest of the people be worshipping idols! God wanted to destroy the rest of the Jews because they were worshipping idols, but when God saw the actions of Chanania, Mishael and Azaria, his anger subsided.
The sages try to fill in some missing details from the story. What happened to Chanania, Mishael and Azaria after they were saved, as they are not directly heard from again? Several options are brought by amoraim and their opinions match those of tannaim. Where was Daniel when Chanania, Mishael and Azaria were thrown into the fire? Several possibilities are offered. According to a braita, God, Daniel and Nevuchadnetzer each did not want Daniel to be there - each for their own reason.
Two false prophets named Achav and Tzidkia were also thrown into a fire by Nevuchadnetzer, but were killed. What is the background story? According to the midrash, Yehoshua the High Priest was sent in with them, but was only singed and came out alive. Why was Yehoshua punished?
In the book of Ruth, Ruth tells Naomi that Boaz gave her six grains of barley. Bar Kapara extrapolated this verse to mean that by giving her six grains, he was alluding to her that six sons would be born to her who were each blessed with six blessings - David, the Messiah, Daniel, Chanania, Mishael and Azaria. Verses are brought to show how each was blessed in six ways. There is a debate, however, about Chanania, Mishael and Azaria's lineage and whether or not they were from the tribe of Judah.
Yishayahu prophesizes to Chizkiyahu that his descendants will be taken to Babylonia and will become sarisim. The Gemara understands this to be referring to Daniel, Chanania, Mishael and Azaria. What is the meaning of the word sarisim in this context? Rav and Rabbi Chanina disagree. Does it mean they were eunuchs? Or does it mean they were cut off from worshipping idols?
The Gemara raises two difficulties against Rav, that they were eunuchs, and one difficulty against Rabbi Chanina, that they were cut off from worshipping idols. The difficulties are brought from verses in Daniel and Yeshayahu but are resolved.
Why was the book of Ezra, which much of it was said and written by Nechemia, not called Nechemia? Two suggestions are brought.