In this month's AJP Audio, Dr. Samuel Wilkinson (Yale University, Associate Director of the Yale Depression Research Program) discusses a study looking at the association of electro-convulsive therapy or ECT on all-cause mortality and suicide in Medicare patients with mood and bipolar disorders. Following that, Dr. Ned Kalin, Editor-in-Chief of the Journal discusses the December issue of AJP.

• Wilkinson interview: Effects of ECT on older patients with mood disorders [00:50]
• A brief history of ECT [01:20]
• A troubled history [02:00]
• A backlash against ECT [02:24]
• Improved techniques and practices [03:32]
• Limitations of past research into ECT [04:20]
• Strength of the study [05:33]
• How patients were matched [05:59]
• Limitations of the present study [07:17]
• Treatment of patients going forward [08:18]
• Difficulties in administering and accessing ECT [09:49]
• Next steps in research into ECT and patients with elevated suicide risk [11:14]
• All-cause mortality and ECT [11:57]
• Kalin interview: The December issue of AJP [13:02]
• Major depressive and bipolar disorders [13:13]
• "Neuromodulation Strategies for the Treatment of Depression" [13:42]
• "Association of ECT With Risks of All-Cause Mortality and Suicide in Older Medicare Patients" [14:19]
• "Efficacy and Safety of Lumateperone for Major Depressive Episodes Associated with Bipolar I or Bipolar II Disorder: A Phase 3 Randomized Placebo-Controlled Trial" [15:29]
• Ostacher editorial [17:44]
• "Association Between Systemic Inflammation and Individual Symptoms of Depression: A Pooled Analysis of 15 Population-Based Cohort Studies" [18:18]
• Pariante editorial [20:42]
• "Coordinate-Based Network Mapping of Brain Structure in Major Depressive Disorder in Younger and Older Adults: A Systematic Review and Meta-Analysis" [21:23]
• Putting the issue into context [23:00]

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