Interview with Elena Polverejan

A conversation in 2017 that led to the creation of the Estimands Framework, a shared language to simplify complexity in clinical trials.

Me and Elena strategically chose depression as their focus for research due to its unique challenges, including efficacy, maintenance, intercurrent events, and time-to-event endpoints.

A collaborative effort between stakeholders has produced a practical guide to help study teams better understand and utilize the Estimands process for clinical trial design.

Getting the support and validation of regulatory bodies was an essential factor in the success of the Estimands Framework.

The Estimands Framework, developed by me and Elena, enhances the pharmaceutical industry by providing a path towards greater precision, clarity, and collaboration in clinical trials.