Dr. David Friedman interviews Dr. David Kessler, former FDA Commissioner and author of Diet, Drugs, and Dopamine, about why diets often fail and how ultra-processed foods hijack the brain's reward system. They discuss the rise of GLP-1 weight loss drugs like Ozempic, its benefits and limitations, and the importance of combining medication with nutrition, exercise, and behavior change for lasting results. Dr. Kessler also emphasizes better food labeling, the dangers of visceral fat, and how brain chemistry drives cravings and relapse.