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We're exploring the integration of AI search within Corpendium and discussing the delicate balance between powerful search capabilities and maintaining medical accuracy. Our team dives deep into the technical challenges and ethical considerations of implementing AI in a trusted medical reference platform.

• AI search struggles with staying confined to just Corpendium's content despite explicit instructions
• RAG (Retrieval Augmented Generation) allows AI to search internal databases while maintaining natural language understanding
• The tension between sensitivity and specificity mirrors clinical decision-making in emergency medicine
• Vector space embeddings help AI understand semantic relationships between medical terms beyond simple keyword matching
• Citations and references are crucial for verifying AI-generated information against human-authored content
• Traditional search still has value, especially in offline modes where large language models aren't available
• Expert human judgment remains essential as AI can make dangerous mistakes despite sounding authoritative
• Editorial teams benefit from AI by automating formatting tasks while focusing human expertise on clinical content
• The system will launch in beta with user feedback mechanisms to continuously improve accuracy
• AI is most valuable as a tool for experts rather than a replacement for medical education and training

AI doesn't replace the learning that medical professionals go through. It's exceptionally helpful in the hands of experts, but always scrutinize what it tells you.

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Mel will be on a trip to Kenya doing some teaching. Show will reboot in mid March. Lts of great interviews coming up!

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Mel interviews Graham Walk of "MD Calc" fame. This episode explores the evolving role of AI in healthcare, focusing on a study that compares ChatGPT's performance to that of human doctors in managing complex medical cases. We discuss the implications of these findings, the potential for misinformation, and the future of AI integration in clinical practice.

• Examination of the BMJ study on AI vs. doctors
• Real-world application of AI in patient care 
• Concerns around AI misdiagnosis and misinformation 
• Future prospects of AI in healthcare settings 
• Impacts of AI integration on workforce and private equity 
• Human-AI collaboration as a path forward

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This episode unravels the complexities of using Ozempic, a GLP-1 receptor agonist, for weight loss—especially among people without diabetes. Dr. Anne Peters highlights the health implications, individual responses to the drug, and the broader context of weight management.

• Examination of Ozempic’s functions and benefits 
• Discussion on who should consider using Ozempic 
• Clarifying misconceptions about weight loss and obesity 
• Insight into the body’s set point and its impact on weight 
• Risks associated with using medications for non-diabetic individuals 
• Emphasizing the need for a multifaceted approach to health 
• Historical context of obesity and diabetes in society 
• Conclusion on prioritizing health over aesthetic standards

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Mel Interviews Sam Ko for an enlightening episode where we explore the extraordinary journey of an ER doctor who switched gears from the chaotic world of emergency medicine to the innovative realm of ketamine therapy. Gain insights into how medical podcasts influenced his path, ultimately leading to the first ER doctor-led ketamine clinic in California. This episode promises a deep dive into the transformative impact of ketamine clinics, the challenges of leaving traditional ER careers, and the successful expansion across the nation through online education.

Our guest shares the meticulous approach taken in his clinic, which blends medical precision with holistic elements for an optimal therapeutic experience. Hear about the importance of setting intentions, the safety measures during administration, and the unique process of integrating music and aromatherapy. We discuss the nuances of different ketamine administration routes, with a special focus on the benefits of intravenous therapy, offering listeners a comprehensive understanding of this emerging treatment and its emotional breakthroughs.

Venturing beyond ketamine, we tackle broader topics such as the necessity of personal experience in psychedelic therapy and the historical and legal landscapes that shape it. Delve into the psychological underpinnings that draw some to high-adrenaline careers like emergency medicine, with reflections on how childhood trauma might influence such career paths. This episode is packed with compelling narratives and expert knowledge, offering a fresh perspective on the evolving world of mental health treatment.

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Mel interviews Karina Sergi, MS, MFT Director, Psychedelic Therapy Training; Director, Diversity, Equity & Inclusion and  Keith Heinzerling, MD Director, Treatment & Research In Psychedelics (TRIP) Center; Addiction Medicine.

We discuss psychedelic associated therapy, ketamine, DMT, Psilocybin,  Hallucinogen persisting perception disorder (HPPD, Ontological shock, Psychnaughts and so much more as we continue our series on mental health treatment options

The Treatment and Research in Psychedelics clinic (TRIP) located at Pacific Neuroscience Institute. Their website:
https://www.pacificneuroscienceinstitute.org/treatment-research-in-psychedelics/

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Mel interviews and is himself interviewed by Sandy Newes, PhD who co-founded the Living Medicine Institute, an online community offering content and training for clinical and medical professionals interested in the legal use of ketamine to address mental health issues. She can be found on LinkedIn here.

Together they discuss Ketamine for depression and PTSD, dosing, Mels personal experience and how to get trained to safely and ethically provide and use this type of treatment. 

There is discussion of mental health diseases and suicidality so please be aware of this particular content.

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Mel interviews the author's of the GPT Vs. Residents NEJM study. How did they do it, why did they do the study and what does it all mean for the future of medical education.

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Mel interviews ER doc and AI expert Justin Schrager whose company vital.io makes patient facing AI for Emergency medicine and inpatient departments. We talk models, hallucinations, the singularity and more. 

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Mel Herbert, MD, and the creators of EM:RAP, UCMAX, CorePendium, and many of the most influential medical education series present a new free podcast: “Dirty White Coat.” Join us twice a month as we dive into all things medicine—from AI to venture capital, long COVID to ketamine, RFK Jr. to Ozempic, and so much more. Created by doctors for clinicians of all levels and anyone interested in medicine, this show delivers expert insights, engaging discussions, and the humor we all desperately need more of!

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