Howie and Harlan are joined by Dr. Eric Topol, a physician and writer who is widely recognized both as a leading researcher and a public voice on medicine and health. They discuss his career turn toward genomics and digital health, and the fight against misinformation on Twitter.  Links: “Adding Salt to Foods and Risk of Cardiovascular Disease” Eric Topol: Ground Truths  Eric Topol: The Creative Destruction of Medicine: How the Digital Revolution Will Create Better Health Care (2011) Eric Topol: The Patient Will See You Now: The Future of Medicine Is in Your Hands (2015)  Eric Topol: Deep Medicine: How Artificial Intelligence Can Make Healthcare Human Again (2019)  Eric Topol on Twitter  Scott Gottlieb on LinkedIn: “The GLP-1s emerge as the largest class of peptide drugs of all time” Learn more about the MBA for Executives program at Yale SOM. Email Howie and Harlan comments or questions.

Dr. Eric Topol: Pushing Medicine into the Future

Howard Forman and Harlan Krumholz, two Yale physician-professors, discuss the latest news and ideas in healthcare and seek out the truth amid the noise. Produced with the Yale School of Management and the Yale School of Public Health. New episodes are available every Thursday.

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Howie and Harlan are joined by Arthur Caplan, Drs. William F. and Virginia Connolly Mitty Professor of Bioethics and founding head of the division of medical ethics at NYU Grossman School of Medicine, to discuss the ethical failings of the pharmaceutical industry and how a community-focused ethos prioritizing justice and protection of the vulnerable would have reshaped the COVID response. Harlan reports on developments in synthetic proteins. Howie recognizes World Malaria Day. Links:  Division of Medical Ethics: NYU Langone  “‘You’ve got bad blood’: The horror of the Tuskegee syphilis experiment”  “When Evil Intrudes”  “Surgeons Perform World’s First Combined Heart Pump And Pig Kidney Transplant—Latest Breakthrough Involving Pig Organ”  “Biden trolls Trump on injecting bleach anniversary”  Frequently Asked Questions on Oregon’s Death With Dignity Act (DWDA)  “A quiet revolution in organ transplant ethics”  Center for Healthcare Ethics: The Provider-Patient Relationship  “Ex-Stanford President’s AI Drug Startup Pulls In $1 Billion in Commitments”  “Protein wrangler, serial entrepreneur, and community builder: Inside David Baker’s brain”  Baker Lab: Home Page  “Atomically accurate de novo design of single-domain antibodies”  National Cancer Institute: Definition of a Monoclonal Antibody  Malaria: World Health Organization   CDC: Malaria’s Impact Worldwide  UNICEF: Ten things you didn’t know about malaria Yale Innovation Summit 2024 Link for the Health & Veritas Livestream at the Yale Innovation Summit Learn more about the MBA for Executives program at Yale SOM. Email Howie and Harlan comments or questions.

Arthur Caplan: Medicine’s Toughest Ethical Questions

Howie and Harlan are joined by Scott Berkowitz ’03, cardiologist and chief population health officer at Johns Hopkins Medicine, to discuss the necessity of moving from fee-for-service to value-based care delivery to improve outcomes for all. Harlan highlights the dangers of misinformation about Ivermectin. Howie reports on the potential conflicts of interest created by device manufacturers’ payments to cardiologists. Links:  Johns Hopkins Medicine: Home  Johns Hopkins Community Health Partnership  “Association of a Care Coordination Model With Health Care Costs and Utilization”  “Planning for the Future of Population Health: The Johns Hopkins Medicine Experience”  “Califf’s long day on Capitol Hill”  “The FDA Deleted Its Viral Ivermectin Tweets. Now There’s Even More Misinformation.”  “Philly Nonprofit Awarded $48 Million to Apply AI in Search for New Uses for Approved Drugs  Posted on March 12, 2024”  “Effect of Early Treatment with Ivermectin among Patients with Covid-19”  “Effect of Ivermectin vs Placebo on Time to Sustained Recovery in Outpatients With Mild to Moderate COVID-19”  “Effect of Higher-Dose Ivermectin for 6 Days vs Placebo on Time to Sustained Recovery in Outpatients With COVID-19”  “Systematic review and meta-analysis of ivermectin for treatment of COVID-19: evidence beyond the hype”  Ivermectin and Covid  “FDA settles lawsuit over ivermectin content that doctors claimed harmed their practice”  “Intravascular Microaxial Left Ventricular Assist Device Manufacturer Payments to Cardiologists and Use of Devices”  “Impact of Industry Payments on Prescribing Patterns for Tumor Necrosis Factor Inhibitors Among Medicare Beneficiaries” Yale Innovation Summit 2024 Learn more about the MBA for Executives program at Yale SOM. Email Howie and Harlan comments or questions.

Scott Berkowitz: Value-Based Care and Population Health

Howie and Harlan are joined by Atheendar Venkataramani, a physician, health economist, and director of the Perelman School of Medicine’s Opportunity for Health Lab, to discuss the powerful role of economic opportunity in population health outcomes. Harlan reports on two studies where treatments’ unexpected benefits leapt ahead of understanding why they work. Howie reflects on the business model of the pharma industry and the market reaction to anti-obesity drugs. Links:  Opportunity for Health | Home  “College Affirmative Action Bans and Smoking and Alcohol Use among Underrepresented Minority Adolescents in the United States: A Difference-in-differences Study”  “Police Killings and Their Spillover Effects on the Mental Health of Black Americans: A Population-based, Quasi-experimental Study” “Officer-Involved Killings of Unarmed Black People and Racial Disparities in Sleep Health“  Behavioral Risk Factor Surveillance System | Home “Building Black Wealth — The Role of Health Systems in Closing the Gap“  KFF | Understanding Mergers Between Hospitals and Health Systems in Different Markets  “In Hospitals, Affordable Housing Gets the Long-Term Investor It Needs”  American College of Cardiology 73rd Annual Scientific Session & Expo  “Semaglutide in Patients with Obesity-Related Heart Failure and Type 2 Diabetes“  “Coronary sinus reducer for the treatment of refractory angina (ORBITA-COSMIC): a randomised, placebo-controlled trial” “A Placebo-Controlled Trial of PCI for Stable Angina“ “Trial of Lixisenatide in Early Parkinson’s Disease“  “The Cream of The Crop: 5 Biotechs That Outrank Most Stocks”  “How High Can Eli Lilly Stock Go? $1,000 A Share, One Analyst Says” Learn more about the MBA for Executives program at Yale SOM. Email Howie and Harlan comments or questions.

Atheendar Venkataramani: Opportunity, Hope, and Health

Howie and Harlan are joined by Kate McEvoy, executive director of the National Association of Medicaid Directors, to discuss the programs’ underappreciated advances in holistically addressing health, housing, and food security. Reflecting on the upcoming election, Harlan notes that facts matter, whether in medicine or politics. Howie reports on the dangers of glyoxylic acid in hair straightening products. Links:  “Trump Leads Biden in Six of Seven Swing States, WSJ Poll Finds” “Takeover: Hitler’s Final Rise to Power”  “The Forgotten History of Hitler’s Establishment Enablers”  The Future of Health Policy in a Partisan United States  “Netflix blockbuster ‘3 Body Problem’ divides opinion and sparks nationalist anger in China”  “The Future of American Democracy Depends on Improving U.S. Health”  Wikipedia | Glyoxylic acid  Kidney Injury and Hair-Straightening Products Containing Glyoxylic Acid  American Cancer Society | Formaldehyde and Cancer Risk  Kaiser Family Foundation | 10 Things to Know About the Unwinding of the Medicaid Continuous Enrollment Provision  Kaiser Family Foundation | Medicaid Postpartum Coverage Extension Tracker  CMS | NHE Fact Sheet  Moral Injuries in Healthcare Workers: What Causes Them and What to Do About Them?  NCDHHS | Healthy Opportunities Pilots  HealthTech4Medicaid | About Learn more about the MBA for Executives program at Yale SOM. Email Howie and Harlan comments or questions.

Kate McEvoy: How Medicaid Is Driving Healthcare Innovation

Howie and Harlan are joined by Margo Harrison, an OB-GYN and femtech entrepreneur, to discuss how innovative solutions to women’s health problems offer deeper understanding and expanded choices. Harlan and Howie each offer a caveat emptor for lightly regulated, unproven supplements and treatments such as Prevagen and hydration spas. Links:  “Prevagen Review: A Word of Caution”  “Prevagen®: Analysis of Clinical Evidence and Its Designation as a ‘#1 Pharmacist Recommended Brand’”  “NY Jury Rules Some Claims About Prevagen Are Misleading”  “Effects of a Supplement Containing Apoaequorin on Verbal Learning in Older Adults in the Community”  Mate Fertility: Home  Dahlia Ventures  Margo Harrison, MD: Assistant Adjoint Professor, OB-GYN-Basic Repro Science  Margo Harrison: LinkedIn  “Use of Cesarean Birth at Mizan Tepi University Teaching Hospital, Mizan Aman, Ethiopia” “Postpartum Contraceptive Use Among Denver-Based Adolescents and Young Adults: Association with Subsequent Repeat Delivery”  “Warnings grow about risky IV drips and injections at unregulated med spas”  “FDA highlights concerns with compounding of drug products by medical offices and clinics under insanitary conditions”  “Drip bar: Should you get an IV on demand?”  “Are Your Therapies FDA Compliant?”

Dr. Eric Topol: Pushing Medicine into the Future

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