7.14.24
Quick Review #178 - #pathology #oralpathology #doctorgallagher #oralsurgery #oralsurgeon #dentist #dentistry #dental
Aphthous Ulcers (Canker Sores)
Key Characteristics:
• Common, non-contagious, and recurrent
• Exact cause often unknown, but may be related to immune response, stress, nutritional deficiencies, or trauma
Clinical Features:
• Occur on non-keratinized mucosa (e.g., inside cheeks, lips, under the tongue)
• Small, round or oval ulcers with a yellowish or white center and a red halo
Signs and Symptoms:
• Painful lesions, especially when eating or speaking
• No systemic symptoms
Histology:
• Superficial ulceration with a fibrinopurulent membrane
• Inflammatory infiltrate mainly composed of lymphocytes, macrophages, and occasional neutrophils
Herpetic Stomatitis
Key Characteristics:
• Caused by Herpes Simplex Virus (HSV), usually HSV-1
• Contagious and often recurrent
Clinical Features:
• Typically affects keratinized mucosa (e.g., gingiva, hard palate)
• Multiple vesicles that rupture to form shallow, painful ulcers
Signs and Symptoms:
• Acute cases often present with fever, malaise, and lymphadenopathy
• Vesicles can coalesce into larger ulcerations
Histology:
• Intraepithelial vesicles and ballooning degeneration of epithelial cells
• Multinucleated giant cells and eosinophilic intranuclear inclusions (Cowdry type A bodies)
• Acantholysis and necrosis of epithelial cells
Erythema Multiforme (EM)
Key Characteristics:
• Hypersensitivity reaction often triggered by infections (e.g., HSV, Mycoplasma pneumoniae) or medications
• Acute and sometimes recurrent
Clinical Features:
• Target or iris-like skin lesions
• Oral lesions can appear on both keratinized and non-keratinized mucosa
• Large, irregular, and painful ulcers
Signs and Symptoms:
• Systemic symptoms like fever, malaise, and arthralgia may be present
• Severe cases can involve ocular and genital lesions (Stevens-Johnson syndrome)
Histology:
• Subepithelial and intraepithelial vesiculation
• Necrosis of basal keratinocytes
• Mixed inflammatory infiltrate with lymphocytes, neutrophils, and eosinophils
References:
1. Petruzzi, M., Galleggiante, S., & della Vella, F. (2022). Oral erythema multiforme after Pfizer-BioNTech COVID-19 vaccination: A report of four cases. BMC Oral Health, 22(1), Article 90.
2. Neville, B. W., Damm, D. D., Allen, C. M., & Chi, A. C. (2016). Oral and Maxillofacial Pathology (4th ed.). Elsevier.
3. Regezi, J. A., Sciubba, J. J., & Jordan, R. C. (2017). Oral Pathology: Clinical Pathologic Correlations (7th ed.). Elsevier.
4. Scully, C., & Porter, S. (2008). Oral mucosal disease: Recurrent aphthous stomatitis. British Journal of Oral and Maxillofacial Surgery, 46(3), 198-206.
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