Full Title: “What are the Key Characteristics & Treatment for the Calcifying Epithelial Odontogenic Tumor (CEOT)?” - 2.8.24
Quick Review #104 - #pathology #oralpathology #doctorgallagher #oralsurgery #oralsurgeon #dentist #dentistry #dental
Calcifying Epithelial Odontogenic Tumors (CEOTs), also known as Pindborg tumors, have several key characteristics:
1. Histological Appearance: They are characterized by the presence of polyhedral epithelial cells with clear, eosinophilic cytoplasm and distinct intercellular bridges. The cells are arranged in sheets and islands within a fibrous stroma.
2. Calcification: CEOTs often contain calcifying structures, including concentric calcified rings known as Liesegang rings, as well as homogenous acellular masses that may resemble enamel matrix.
3. Amyloid Deposits: A unique feature of CEOTs is the presence of amyloid-like material, which stains positively with Congo red and exhibits apple-green birefringence under polarized light.
4. Radiographic Features: On radiographs, these tumors may show a mixed radiolucent-radiopaque pattern due to the presence of calcified material. They can present as unilocular or multilocular lesions with well-defined or irregular borders.
5. Clinical Presentation: Patients with CEOT usually present with a slow-growing, painless mass in the jaw, which may cause expansion of the bone. Teeth displacement and root resorption can also occur.
6. Location Preference: While CEOTs can occur in both the mandible and maxilla, they are more commonly found in the mandible, particularly in the premolar and molar regions.
7. Potential for Recurrence: CEOTs are generally benign but can exhibit aggressive behavior, with a propensity for local invasion and recurrence after surgical removal.
8. Treatment: Complete surgical excision with 1.0-1.5 cm margins is the treatment of choice. In cases of aggressive or recurrent tumors, a more radical surgical approach may be necessary.
9. Prognosis: The overall prognosis for CEOT is good, but due to the potential for recurrence, long-term follow-up is recommended.
CEOTs are considered rare among odontogenic tumors and are distinct due to their histopathological features, potential for calcification, and the presence of amyloid deposits.
References:
1. Akay, M. C., Tetik, A., & Zeytinoğlu, M. (2014). The Calcifying Epithelial Odontogenic Tumor (Pindborg Tumor): A Case Report. Open Access Library Journal. https://doi.org/10.4236/OALIB.1101036
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