Dr RR Baliga's "Got Knowledge Doc" Podkast

By Dr RR Baliga, MD, MBAScience Education Natural Sciences

Dr RR Baliga's "Got Knowledge Doc" Podkast episodes

May 21, 2025 💥 Old Drugs, New Power: Amiloride vs Spironolactone in Resistant Hypertension
🩺 New hope for #ResistantHypertension!

A 12-week RCT 🇰🇷 shows 💊 amiloride is noninferior to spironolactone in lowering SBP 📉

Fewer side effects, similar BP drop!

But spironolactone may still reign 👑 for organ protection 🫀🧠

🧪 #Hypertension #Cardiology #JAMA2025
5 min
May 21, 2025 🧪 Precision for One, Promise for Many: CRISPR Meets the Clinic--A New Era in Rare Disease Therapy
🧬✨ A baby with deadly CPS1 deficiency (which results in elevated ammonia levels) gets a custom-made gene edit—delivered by lipid nanoparticles—in just 6 months! 🚀

Ammonia levels down, no hospitalizations, and hope up.

N-of-1? More like Future-of-Many. 💡👶🔬 #GeneTherapy #PrecisionMedicine #RareDisease
7 min
May 20, 2025 🔥 Smoldering Systems: Staging Systemic Metabolic Disorder Before It Ignites
🚨 New framework alert!

Systemic Metabolic Disorder (SMD) gets a clinical staging makeover 🧬

From reversible risks 🌱 to systemic damage 🔥—this EAS consensus guides timely, targeted care 🎯

#MetabolicHealth #Cardiology #PrecisionMedicine #SMD 🩺📊
4 min
May 20, 2025 Dr RR Baliga's Philosophical Discourses: Pyrrho (Greece, c. 360–270 BCE) – Founder of Pyrrhonism
Pyrrho of Elis (c. 360–270 BCE) was an ancient Greek philosopher and founder of Pyrrhonism, a school of philosophical skepticism.

He advocated for epoché (suspension of judgment) as a path to ataraxia (peace of mind).

Influenced by his travels to India with Alexander the Great, Pyrrho believed that nothing could be definitively known and that by refraining from beliefs, one could achieve tranquility.

His teachings laid the foundation for later skeptical thought in philosophy and medicine.
5 min
May 19, 2025 🧬 Target ANGPTL3, Tame the Lipids, Transform the Risk
🧬 New hope for lipid warriors!

Solbinsiran (siRNA) slashed apoB 🩸, TGs 🍟, LDL-C 💔 & liver fat 🫀 in just 205 pts with mixed dyslipidaemia.

Safe ✅ Durable ✅ Quarterly dosing? Maybe ✅

Let's talk outcomes! 🎯

#PROLONGANG3 #RNAtherapy #CardioTwitter #LipidLowering
5 min
May 19, 2025 🏥 Watch, Wait, or Wage War? The Prostate Cancer Playbook
🧔‍♂️ Prostate cancer is the most common cancer in US men.

🧪 PSA testing? 🔍 It's all about shared decision-making.

🧬 From Gleason scores to PSMA-PET, precision reigns.

💉 ARPIs & ADT = survival gains in advanced disease.

⚖️ Screen smart. Treat right. Save lives.

#ProstateCancer #MensHealth #Oncology 🧠💪
4 min
May 18, 2025 Triglycerides, Trials, and Triumph 🚧📉🏆: The ANGPTL4 Story
🚨 New frontier in lipid-lowering!

🧬 Blocking ANGPTL4 with MAR001 slashed triglycerides & remnant cholesterol by >50%

🛡️ Safe, well-tolerated, no lymph node issues

💡 Promising for residual ASCVD risk

Next step? Big trials, big answers! 📊🫀

#LipidScience #CardioTwitter #PrecisionMedicine
6 min
May 18, 2025 Cracking the Code of Short Sleepers 🧠🔍😴
Why do some people sleep just 4 hours and feel great? 😴💪

A new study links the 🧬 SIK3-N783Y mutation to natural short sleep!

Less sleep, more delta power 🧠⚡

🚀🛌

#SleepScience #Genetics #SIK3 #ShortSleepers
4 min
May 17, 2025 🔥 IL-6, Inflammation, and Irregular Beats: The Cytokine Cascade Driving Post-Op AFib
🫀 Post-op AFib? Blame IL-6!

New @JClinInvest study shows IL-6 ➡️ STAT3 ➡️ CaMKII ➡️ RyR2 leak triggers post-op AFib.

🧬 Macrophage IL-6Rα is the match.

🧯 TTI-101 & KN-93 douse the flame.

⚡ Targeting IL-6 signaling = future Rx?

#CardioTwitter #AFib #Inflammation #JCI
5 min
May 17, 2025 Good Carbs, Great Life, Golden Years 🥦✨👵
🥦🍎 Want to age like fine wine? Choose high-quality carbs!

In a 32-year study of 47K women, fiber-rich carbs (from 🌾, 🥗, 🌱) boosted odds of healthy aging 🧠💪🧘‍♀️

Refined carbs? Not so kind.

#HealthyAging #NutritionMatters #WomensHealth 🧬📊💚
5 min